PDLIM1

PDZ and LIM domain protein 1 is a protein that in humans is encoded by the PDLIM1 gene.^[5][6]

PDLIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X62, 2PKT
Identifiers
Aliases	PDLIM1, CLIM1, CLP-36, CLP36, HEL-S-112, hCLIM1, PDZ and LIM domain 1
External IDs	OMIM: 605900; MGI: 1860611; HomoloGene: 9643; GeneCards: PDLIM1; OMA:PDLIM1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.33 Start 95,237,572 bp[1] End 95,291,012 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 40,209,617 bp[2] End 40,260,286 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung nasal epithelium mucosa of urinary bladder right lung pericardium gingival epithelium upper lobe of lung olfactory zone of nasal mucosa palpebral conjunctiva upper lobe of left lung Top expressed in ileum placenta jejunum duodenum esophagus colon uterus zygote lens genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity metal ion binding cadherin binding involved in cell-cell adhesion actin binding muscle alpha-actinin binding Cellular component cytoplasm cytoskeleton focal adhesion transcription regulator complex Z discdkac stress fiber filamentous actin Biological process response to hypoxia regulation of transcription, DNA-templated response to oxidative stress cell-cell adhesion positive regulation of nucleic acid-templated transcription heart development actin cytoskeleton organization muscle structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9124 54132 Ensembl ENSG00000107438 ENSMUSG00000055044 UniProt O00151 O70400 RefSeq (mRNA) NM_020992 NM_016861 RefSeq (protein) NP_066272 NP_058557 Location (UCSC) Chr 10: 95.24 – 95.29 Mb Chr 19: 40.21 – 40.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PDLIM1 has been shown to interact with:

• Actinin alpha 4,^[7][8]
• Actinin, alpha 1,^[8][9]
• Estrogen receptor alpha,^[10] and
• RNF12.^[10]