PEX16

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.^[5][6]

PEX16
Identifiers
Aliases	PEX16, PBD8A, PBD8B, peroxisomal biogenesis factor 16
External IDs	OMIM: 603360; MGI: 1338829; HomoloGene: 3537; GeneCards: PEX16; OMA:PEX16 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 45,909,663 bp[1] End 45,918,812 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 92,205,021 bp[2] End 92,211,562 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex granulocyte right lobe of liver anterior pituitary C1 segment body of pancreas mucosa of transverse colon endothelial cell right frontal lobe anterior cingulate cortex Top expressed in left lobe of liver morula right kidney lip brown adipose tissue subcutaneous adipose tissue white adipose tissue gastrula duodenum proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding protein binding Cellular component integral component of membrane peroxisomal membrane peroxisome endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of peroxisomal membrane Biological process protein targeting to peroxisome protein localization to endoplasmic reticulum peroxisome membrane biogenesis peroxisome organization protein import into peroxisome matrix protein to membrane docking ER-dependent peroxisome organization protein import into peroxisome membrane ER-dependent peroxisome localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9409 18633 Ensembl ENSG00000121680 ENSMUSG00000027222 UniProt Q9Y5Y5 Q91XC9 RefSeq (mRNA) NM_004813 NM_057174 NM_145122 RefSeq (protein) NP_004804 NP_476515 NP_660104 Location (UCSC) Chr 11: 45.91 – 45.92 Mb Chr 2: 92.21 – 92.21 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described.^[6]

Interactions

PEX16 has been shown to interact with PEX19.^[7]