PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.^[5]

PFKFB2
Identifiers
Aliases	PFKFB2, PFK-2/FBPase-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
External IDs	OMIM: 171835; MGI: 107815; HomoloGene: 88554; GeneCards: PFKFB2; OMA:PFKFB2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 207,034,366 bp[1] End 207,081,024 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 130,616,919 bp[2] End 130,656,990 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans oocyte right lobe of thyroid gland left lobe of thyroid gland gastrocnemius muscle rectum apex of heart duodenum anterior pituitary left ventricle Top expressed in neural layer of retina spermatocyte islet of Langerhans spermatid superior frontal gyrus pineal gland lumbar subsegment of spinal cord cerebellar cortex dentate gyrus of hippocampal formation granule cell primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding kinase activity protein binding catalytic activity fructose-2,6-bisphosphate 2-phosphatase activity hydrolase activity ATP binding protein kinase binding 6-phosphofructo-2-kinase activity kinase binding Cellular component cytoplasm cytosol nucleus nucleoplasm Biological process lactate metabolic process glycolytic process phosphorylation fructose metabolic process response to glucose positive regulation of glucokinase activity fructose 2,6-bisphosphate metabolic process pyruvate metabolic process glucose catabolic process metabolism positive regulation of insulin secretion dephosphorylation carbohydrate phosphorylation positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5208 18640 Ensembl ENSG00000123836 ENSMUSG00000026409 UniProt O60825 P70265 RefSeq (mRNA) NM_001018053 NM_006212 NM_001162415 NM_001162416 NM_008825 NM_001368843 RefSeq (protein) NP_001018063 NP_006203 NP_001155887 NP_001155888 NP_032851 NP_001355772 Location (UCSC) Chr 1: 207.03 – 207.08 Mb Chr 1: 130.62 – 130.66 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.^[5]

Interactions

PFKFB2 has been shown to interact with YWHAQ.^[6]