PHC2

Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.^[5][6][7]

PHC2
Identifiers
Aliases	PHC2, EDR2, HPH2, PH2, polyhomeotic homolog 2
External IDs	OMIM: 602979; MGI: 1860454; HomoloGene: 75090; GeneCards: PHC2; OMA:PHC2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.1 Start 33,323,623 bp[1] End 33,431,052 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 62.12 cM Start 128,548,495 bp[2] End 128,646,674 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung tibial arteries gastric mucosa tibial nerve ascending aorta left coronary artery ganglionic eminence upper lobe of left lung Descending thoracic aorta left uterine tube Top expressed in Rostral migratory stream external carotid artery internal carotid artery ventricular zone medial ganglionic eminence genital tubercle secondary oocyte zygote gray matter layer of cerebellum primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding identical protein binding metal ion binding zinc ion binding Cellular component heterochromatin PRC1 complex PcG protein complex nucleus nucleoplasm Biological process spermatogenesis multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1912 54383 Ensembl ENSG00000134686 ENSMUSG00000028796 UniProt Q8IXK0 Q9QWH1 RefSeq (mRNA) NM_004427 NM_198040 NM_001330488 NM_001195083 NM_001195130 NM_018774 RefSeq (protein) NP_001317417 NP_004418 NP_932157 NP_001182012 NP_001182059 NP_061244 Location (UCSC) Chr 1: 33.32 – 33.43 Mb Chr 4: 128.55 – 128.65 Mb PubMed search [3] [4]
Wikidata
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Function

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

PHC2 has been shown to interact with MAPKAPK2,^[8] PHC1,^[5][9] BMI1^[5] and MCRS1.^[9]