PHF2

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene.^[5]

PHF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KQI, 3PTR, 3PU3, 3PU8, 3PUA, 3PUS
Identifiers
Aliases	PHF2, CENP-35, GRC5, JHDM1E, PHD finger protein 2, KDM7C
External IDs	OMIM: 604351; MGI: 1338034; HomoloGene: 3934; GeneCards: PHF2; OMA:PHF2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 93,576,584 bp[1] End 93,679,587 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 24.96 cM Start 48,955,226 bp[2] End 49,024,595 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right hemisphere of cerebellum cerebellar vermis tendon of biceps brachii internal globus pallidus body of uterus anterior pituitary left ovary canal of the cervix Top expressed in ascending aorta aortic valve thymus genital tubercle ventricular zone lacrimal gland submandibular gland lumbar subsegment of spinal cord ganglionic eminence ureter More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding histone H3-methyl-lysine-9 demethylase activity transcription coactivator activity dioxygenase activity metal ion binding methylated histone binding protein binding oxidoreductase activity histone demethylase activity zinc ion binding Cellular component nucleoplasm chromosome nucleolus chromosome, centromeric region kinetochore nucleus Biological process regulation of transcription, DNA-templated histone H3-K9 demethylation protein demethylation transcription, DNA-templated negative regulation of ribosomal DNA heterochromatin assembly liver development chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5253 18676 Ensembl ENSG00000197724 ENSMUSG00000038025 UniProt O75151 Q9WTU0 RefSeq (mRNA) NM_005392 NM_024517 NM_011078 RefSeq (protein) NP_005383 NP_035208 Location (UCSC) Chr 9: 93.58 – 93.68 Mb Chr 13: 48.96 – 49.02 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys₄-His-Cys₃ arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.