PIK3R2

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.^[4][5]

PIK3R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KT1, 2XS6, 3MTT, 3O5Z
Identifiers
Aliases	PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, phosphoinositide-3-kinase regulatory subunit 2
External IDs	OMIM: 603157; MGI: 1098772; HomoloGene: 3687; GeneCards: PIK3R2; OMA:PIK3R2 - orthologs
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8 B3.3|8 34.15 cM Start 71,220,820 bp[1] End 71,229,357 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence stromal cell of endometrium prefrontal cortex hippocampus proper superior frontal gyrus left adrenal gland nucleus accumbens Temporal Lobe Amygdala caudate nucleus Top expressed in primary visual cortex striatum of neuraxis superior frontal gyrus hippocampus proper olfactory bulb Cerebellum ganglionic eminence lip dentate gyrus of hippocampal formation granule cell cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol 3-kinase regulator activity receptor tyrosine kinase binding 1-phosphatidylinositol-3-kinase regulator activity protein binding protein heterodimerization activity protein phosphatase binding GTPase activator activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphotyrosine residue binding 1-phosphatidylinositol-3-kinase activity Cellular component cytosol phosphatidylinositol 3-kinase complex nucleus Biological process Fc-gamma receptor signaling pathway involved in phagocytosis cellular glucose homeostasis response to endoplasmic reticulum stress Fc-epsilon receptor signaling pathway phosphatidylinositol phosphate biosynthetic process vascular endothelial growth factor receptor signaling pathway regulation of autophagy regulation of phosphatidylinositol 3-kinase activity cellular response to insulin stimulus protein transport phosphatidylinositol 3-kinase signaling T cell receptor signaling pathway regulation of small GTPase mediated signal transduction phosphatidylinositol-mediated signaling leukocyte migration positive regulation of transcription by RNA polymerase II signal transduction insulin receptor signaling pathway positive regulation of GTPase activity phosphatidylinositol-3-phosphate biosynthetic process negative regulation of MAPK cascade positive regulation of protein kinase B signaling positive regulation of protein import into nucleus phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5296 18709 Ensembl n/a ENSMUSG00000031834 UniProt O00459 O08908 RefSeq (mRNA) NM_005027 NM_008841 RefSeq (protein) NP_005018 NP_032867 Location (UCSC) n/a Chr 8: 71.22 – 71.23 Mb PubMed search [2] [3]
Wikidata
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A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.^[6]

Interactions

PIK3R2 has been shown to interact with:

• CRKL^[7]
• Cbl gene,^[8][9]
• Epidermal growth factor,^[10]
• FYN,^[10]
• HER2/neu,^[10]
• Macrophage colony-stimulating factor,^[10] and
• PIK3CD.^[11]

Clinical relevance

PIK3R2 mutations were recently shown to be associated with polymicrogyria.^[12]