PLCB3

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.^[5][6]

PLCB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OHM, 4GNK, 4QJ3, 4QJ4, 4QJ5
Identifiers
Aliases	PLCB3, phospholipase C beta 3, SMDCD
External IDs	OMIM: 600230; MGI: 104778; HomoloGene: 47960; GeneCards: PLCB3; OMA:PLCB3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,251,530 bp[1] End 64,269,150 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 5.1 cM Start 6,929,693 bp[2] End 6,953,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon tendon of biceps brachii duodenum buccal mucosa cell right adrenal gland ectocervix left adrenal cortex stromal cell of endometrium right adrenal cortex right coronary artery Top expressed in crypt of lieberkuhn of small intestine duodenum jejunum lumbar spinal ganglion ileum lip left colon cumulus cell migratory enteric neural crest cell granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding signal transducer activity phosphoric diester hydrolase activity hydrolase activity phosphatidylinositol phospholipase C activity cadherin binding protein binding calmodulin binding phospholipase C activity Cellular component cytosol membrane nucleoplasm protein-containing complex postsynaptic cytosol Biological process intracellular signal transduction lipid metabolism inositol phosphate metabolic process lipid catabolic process regulation of systemic arterial blood pressure signal transduction Wnt signaling pathway, calcium modulating pathway G protein-coupled receptor signaling pathway inositol trisphosphate biosynthetic process phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5331 18797 Ensembl ENSG00000149782 ENSMUSG00000024960 UniProt Q01970 P51432 RefSeq (mRNA) NM_000932 NM_001184883 NM_001316314 NM_001290349 NM_008874 RefSeq (protein) NP_000923 NP_001171812 NP_001303243 NP_001277278 NP_032900 Location (UCSC) Chr 11: 64.25 – 64.27 Mb Chr 19: 6.93 – 6.95 Mb PubMed search [3] [4]
Wikidata
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The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This enzyme is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.^[7]