Sodium-hydrogen exchange regulatory cofactor 2

Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 (solute carrier family 9 isoform A3 regulatory factor 2) gene.^[5][6]

SLC9A3R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D11, 2HE4, 2OCS, 4P0C
Identifiers
Aliases	SLC9A3R2, E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1, Sodium-hydrogen exchange regulatory cofactor 2, SLC9A3 regulator 2
External IDs	OMIM: 606553; MGI: 1890662; HomoloGene: 56962; GeneCards: SLC9A3R2; OMA:SLC9A3R2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,025,356 bp[1] End 2,039,026 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,858,260 bp[2] End 24,869,301 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lung right lobe of liver upper lobe of left lung right lobe of thyroid gland right auricle of heart right coronary artery left lobe of thyroid gland left uterine tube left coronary artery Top expressed in external carotid artery aortic valve motor neuron internal carotid artery ascending aorta right lung right lung lobe carotid body left lung right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity phosphatase binding beta-catenin binding signaling receptor binding protein C-terminus binding protein binding cadherin binding Cellular component plasma membrane extracellular exosome apical plasma membrane membrane endomembrane system nucleus focal adhesion Biological process protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9351 65962 Ensembl ENSG00000065054 ENSMUSG00000002504 UniProt Q15599 Q9JHL1 RefSeq (mRNA) NM_001130012 NM_001252073 NM_001252075 NM_001252076 NM_004785 NM_023055 NM_023449 NM_001357796 RefSeq (protein) NP_001123484 NP_001239002 NP_001239004 NP_001239005 NP_004776 NP_075542 NP_075938 NP_001344725 Location (UCSC) Chr 16: 2.03 – 2.04 Mb Chr 17: 24.86 – 24.87 Mb PubMed search [3] [4]
Wikidata
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NHERF-2 is a scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. It is necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. In addition, it may also act as scaffold protein in the nucleus.

Function

This regulatory protein (factor) interacts with a sodium/hydrogen exchanger NHE3 (SLC9A3) in the brush border membrane of the proximal tubule, small intestine, and colon that plays a major role in transepithelial sodium absorption. SLC9A3R2, as well as SLC9A3R1 and protein kinase A phosphorylation, may play a role in NHE3 regulation.^[7]

Interactions

Sodium-hydrogen exchange regulatory cofactor 2 has been shown to interact with SGK,^[8][9] Actinin alpha 4,^[10] Parathyroid hormone receptor 1,^[11] Phosphoinositide-dependent kinase-1,^[8] EZR,^[12][13] PODXL,^[14][15][16] Cystic fibrosis transmembrane conductance regulator^[17] and PLCB3.^[18]

See also

• Solute carrier family