PLRG1

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.^[5]

PLRG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YVD
Identifiers
Aliases	PLRG1, Cwc1, PRL1, PRP46, PRPF46, TANGO4, pleiotropic regulator 1
External IDs	OMIM: 605961; MGI: 1858197; HomoloGene: 2004; GeneCards: PLRG1; OMA:PLRG1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 154,535,005 bp[1] End 154,550,400 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 82,962,829 bp[2] End 82,979,662 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon islet of Langerhans smooth muscle tissue body of uterus left lobe of thyroid gland palpebral conjunctiva right lobe of thyroid gland rectum right uterine tube Top expressed in primitive streak primary oocyte maxillary prominence mandibular prominence medial ganglionic eminence endocardial cushion somite abdominal wall epiblast superior cervical ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component DNA replication factor A complex Cul4-RING E3 ubiquitin ligase complex catalytic step 2 spliceosome nuclear membrane spliceosomal complex precatalytic spliceosome Prp19 complex fibrillar center nucleoplasm nuclear speck U2-type catalytic step 2 spliceosome nucleus Biological process protein localization to nucleus positive regulation of G1/S transition of mitotic cell cycle mRNA processing RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5356 53317 Ensembl ENSG00000171566 ENSMUSG00000027998 UniProt O43660 Q922V4 RefSeq (mRNA) NM_002669 NM_001201564 NM_016784 RefSeq (protein) NP_001188493 NP_002660 NP_058064 Location (UCSC) Chr 4: 154.54 – 154.55 Mb Chr 3: 82.96 – 82.98 Mb PubMed search [3] [4]
Wikidata
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Interactions

PLRG1 has been shown to interact with CDC5L.^[6][7][8][9]