Phospholipid scramblase 1

Phospholipid scramblase 1 (PL scramblase 1) is an enzyme that in humans is encoded by the PLSCR1 gene.^[5][6]

PLSCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y2A
Identifiers
Aliases	PLSCR1, MMTRA1B, phospholipid scramblase 1
External IDs	OMIM: 604170; MGI: 893575; HomoloGene: 41418; GeneCards: PLSCR1; OMA:PLSCR1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q24 Start 146,515,180 bp[1] End 146,544,856 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 92,131,803 bp[2] End 92,154,331 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva monocyte caput epididymis gallbladder germinal epithelium pericardium mucosa of sigmoid colon tail of epididymis epithelium of nasopharynx rectum Top expressed in ileum granulocyte colon yolk sac jejunum duodenum proximal tubule right kidney lung human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipid scramblase activity DNA binding calcium ion binding CD4 receptor binding SH3 domain binding epidermal growth factor receptor binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding enzyme binding Cellular component integral component of membrane cytosol Golgi apparatus membrane extracellular matrix plasma membrane integral component of plasma membrane nucleolus membrane raft extracellular exosome nucleus cytoplasm perinuclear region of cytoplasm collagen-containing extracellular matrix Biological process phosphatidylserine biosynthetic process regulation of mast cell activation plasma membrane phospholipid scrambling positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity response to interferon-beta regulation of Fc receptor mediated stimulatory signaling pathway platelet activation negative regulation of viral genome replication positive regulation of gene expression defense response to virus acute-phase response positive regulation of innate immune response positive regulation of transcription by RNA polymerase II apoptotic process transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5359 22038 Ensembl ENSG00000188313 ENSMUSG00000032369 UniProt O15162 Q9JJ00 RefSeq (mRNA) NM_021105 NM_001363872 NM_001363874 NM_011636 RefSeq (protein) NP_066928 NP_001350801 NP_001350803 NP_035766 Location (UCSC) Chr 3: 146.52 – 146.54 Mb Chr 9: 92.13 – 92.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PLSCR1 has been shown to interact with:

• CPSF6,^[7]
• Epidermal growth factor receptor,^[8]
• NEU4,^[7]
• SHC1,^[8][9]
• SLPI,^[10] and
• TFG.^[7]

See also

• Scramblase