CPSF6

Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.^[5][6][7]

CPSF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P5T, 3P6Y, 3Q2S, 3Q2T, 4B4N, 4U0A, 4U0B, 4WYM
Identifiers
Aliases	CPSF6, CFIM, CFIM68, HPBRII-4, HPBRII-7, cleavage and polyadenylation specific factor 6, CFIM72
External IDs	OMIM: 604979; MGI: 1913948; HomoloGene: 134126; GeneCards: CPSF6; OMA:CPSF6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 69,239,569 bp[1] End 69,274,358 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 117,180,578 bp[2] End 117,215,920 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence bone marrow cells Achilles tendon ventricular zone tonsil left ovary right ovary appendix sural nerve endometrium Top expressed in superior cervical ganglion hand otolith organ utricle mandibular prominence cumulus cell trigeminal ganglion maxillary prominence abdominal wall ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding RNA binding nucleic acid binding ribosomal large subunit binding exon-exon junction complex binding Cellular component paraspeckles membrane nucleus nucleoplasm nuclear speck mRNA cleavage factor complex perichromatin fibrils cytoplasm mRNA cleavage and polyadenylation specificity factor complex interchromatin granule ribonucleoprotein complex Biological process mRNA polyadenylation mRNA processing protein tetramerization positive regulation of RNA export from nucleus protein heterotetramerization pre-mRNA cleavage required for polyadenylation mRNA alternative polyadenylation messenger ribonucleoprotein complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11052 432508 Ensembl ENSG00000111605 ENSMUSG00000055531 UniProt Q16630 Q6NVF9 RefSeq (mRNA) NM_001300947 NM_007007 NM_001013391 NM_001310609 RefSeq (protein) NP_001287876 NP_008938 NP_001013409 NP_001297538 Location (UCSC) Chr 12: 69.24 – 69.27 Mb Chr 10: 117.18 – 117.22 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.^[7]

Interactions

CPSF6 has been shown to interact with WWP1^[8] and PLSCR1.^[8]

CPSF6 plays an important role in the nuclear import and integration of HIV-1 capsids.^[9]