PLXNB1

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.^[5][6][7]

PLXNB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JPH, 2OS6, 2R2O, 2REX, 3HM6, 3OL2, 3SU8, 3SUA
Identifiers
Aliases	PLXNB1, PLEXIN-B1, PLXN5, SEP, plexin B1
External IDs	OMIM: 601053; MGI: 2154238; HomoloGene: 130508; GeneCards: PLXNB1; OMA:PLXNB1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,403,854 bp[1] End 48,430,086 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 108,924,457 bp[2] End 108,948,985 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland left lobe of thyroid gland popliteal artery tibial arteries gastric mucosa ventricular zone skin of abdomen skin of leg right coronary artery Top expressed in otic vesicle neural layer of retina lumbar subsegment of spinal cord Rostral migratory stream medullary collecting duct ventricular zone otolith organ utricle retinal pigment epithelium lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activating protein binding semaphorin receptor activity semaphorin receptor binding protein binding transmembrane signaling receptor activity GTPase activator activity signaling receptor activity Cellular component integral component of membrane membrane plasma membrane semaphorin receptor complex integral component of plasma membrane extracellular region intracellular anatomical structure Biological process ossification involved in bone maturation negative regulation of cell adhesion neuron projection morphogenesis intracellular signal transduction positive regulation of axonogenesis positive regulation of GTPase activity regulation of cell shape axon extension negative regulation of osteoblast proliferation positive regulation of phosphatidylinositol 3-kinase signaling cell migration regulation of cytoskeleton organization semaphorin-plexin signaling pathway signal transduction semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis regulation of GTPase activity G protein-coupled receptor signaling pathway regulation of cell migration semaphorin-plexin signaling pathway involved in axon guidance inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5364 235611 Ensembl ENSG00000164050 ENSMUSG00000053646 UniProt O43157 Q8CJH3 RefSeq (mRNA) NM_001130082 NM_002673 NM_172775 RefSeq (protein) NP_001123554 NP_002664 NP_766363 Location (UCSC) Chr 3: 48.4 – 48.43 Mb Chr 9: 108.92 – 108.95 Mb PubMed search [3] [4]
Wikidata
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Function

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.^[8] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.^[9]

Interactions

PLXNB1 has been shown to interact with ARHGEF12,^[10] Rnd1^[11] and ARHGEF11.^{[10][11][12][13]}