POLR2B

DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the POLR2B gene.^[5][6]

POLR2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2B, POL2RB, RPB2, hRPB140, hsRPB2, polymerase (RNA) II subunit B, RNA polymerase II subunit B
External IDs	OMIM: 180661; MGI: 2388280; HomoloGene: 722; GeneCards: POLR2B; OMA:POLR2B - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 56,977,722 bp[1] End 57,031,158 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.3 Start 77,457,994 bp[2] End 77,497,171 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx germinal epithelium endothelial cell middle temporal gyrus tibia human penis gingival epithelium Brodmann area 23 parietal pleura Achilles tendon Top expressed in saccule otic placode otic vesicle primitive streak hair follicle ciliary body ureter genital tubercle medullary collecting duct vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding nucleotidyltransferase activity ribonucleoside binding RNA polymerase II activity chromatin binding metal ion binding DNA-directed 5'-3' RNA polymerase activity protein binding RNA binding Cellular component membrane RNA polymerase II, core complex nucleus nucleoplasm Biological process mRNA splicing, via spliceosome somatic stem cell population maintenance transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II positive regulation of viral transcription transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway transcription, DNA-templated RNA metabolic process regulation of gene silencing by miRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5431 231329 Ensembl ENSG00000047315 ENSMUSG00000029250 UniProt P30876 Q8CFI7 RefSeq (mRNA) NM_001303269 NM_000938 NM_001303268 NM_153798 RefSeq (protein) NP_000929 NP_001290197 NP_001290198 NP_722493 Location (UCSC) Chr 4: 56.98 – 57.03 Mb Chr 5: 77.46 – 77.5 Mb PubMed search [3] [4]
Wikidata
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This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.^[7]

Interactions

POLR2B has been shown to interact with POLR2C,^[8] POLR2E,^[8] POLR2H^[8] and POLR2L.^[8]