POLR2E

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.^[5]

POLR2E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IY6, 5IY9, 5IY8, 5IYA, 5IYB, 5IY7, 5IYC, 5IYD
Identifiers
Aliases	POLR2E, RPABC1, RPB5, XAP4, hRPB25, hsRPB5, polymerase (RNA) II subunit E, RNA polymerase II subunit E, RNA polymerase II, I and III subunit E
External IDs	OMIM: 180664; MGI: 1913670; HomoloGene: 2018; GeneCards: POLR2E; OMA:POLR2E - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,086,574 bp[1] End 1,095,380 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 79,871,783 bp[2] End 79,875,629 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right lobe of liver prefrontal cortex right frontal lobe muscle of thigh muscle layer of sigmoid colon right adrenal gland popliteal artery abdominal fat tibial arteries Top expressed in yolk sac embryo morula embryo somite blastocyst epiblast mandibular prominence maxillary prominence otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II activity RNA polymerase III activity protein binding RNA polymerase I activity DNA-directed 5'-3' RNA polymerase activity Cellular component cytosol RNA polymerase I complex RNA polymerase III complex RNA polymerase II, core complex nucleus nucleoplasm Biological process termination of RNA polymerase I transcription mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter viral process transcription by RNA polymerase III fibroblast growth factor receptor signaling pathway snRNA transcription by RNA polymerase II RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5434 66420 Ensembl ENSG00000099817 ENSMUSG00000004667 UniProt P19388 Q80UW8 RefSeq (mRNA) NM_002695 NM_001316323 NM_001316324 NM_025554 RefSeq (protein) NP_001303252 NP_001303253 NP_002686 NP_079830 Location (UCSC) Chr 19: 1.09 – 1.1 Mb Chr 10: 79.87 – 79.88 Mb PubMed search [3] [4]
Wikidata
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This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.^[6]

Interactions

POLR2E has been shown to interact with TAF15,^[7] POLR2C,^[8] POLR2G,^[8] POLR2H,^[8] POLR2A,^[8] POLR2B,^[8] POLR2L^[8] and GTF2F2.^[9]