POLR3D

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.^[5][6][7]

POLR3D
Identifiers
Aliases	POLR3D, BN51T, RPC4, RPC53, TSBN51, polymerase (RNA) III subunit D, RNA polymerase III subunit D, C53
External IDs	OMIM: 187280; MGI: 1914315; HomoloGene: 1303; GeneCards: POLR3D; OMA:POLR3D - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,245,133 bp[1] End 22,254,601 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 70,676,197 bp[2] End 70,680,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium Achilles tendon gastrocnemius muscle muscle of thigh islet of Langerhans ventricular zone ganglionic eminence left testis right testis Top expressed in otic placode saccule otic vesicle yolk sac tail of embryo ventricular zone muscle of thigh epiblast embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding chromatin binding RNA polymerase III activity Cellular component RNA polymerase III complex nucleus nucleoplasm cytosol nuclear speck Biological process positive regulation of interferon-beta production immune system process defense response to virus positive regulation of innate immune response transcription by RNA polymerase III innate immune response positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 661 67065 Ensembl ENSG00000168495 ENSMUSG00000000776 UniProt P05423 Q91WD1 RefSeq (mRNA) NM_001722 NM_001164082 NM_025945 RefSeq (protein) NP_001713 NP_001157554 NP_080221 Location (UCSC) Chr 8: 22.25 – 22.25 Mb Chr 14: 70.68 – 70.68 Mb PubMed search [3] [4]
Wikidata
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This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.^[7]

Interactions

POLR3D has been shown to interact with POLR3E.^[5]