PPP1CC

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.^[5]

PPP1CC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IT6, 1JK7, 1U32, 2BCD, 2BDX, 4UT2, 4UT3
Identifiers
Aliases	PPP1CC, PP-1G, PP1C, PPP1G, protein phosphatase 1 catalytic subunit gamma
External IDs	OMIM: 176914; MGI: 3647492; HomoloGene: 100608; GeneCards: PPP1CC; OMA:PPP1CC - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,719,680 bp[1] End 110,742,939 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 7|7 F2 Start 122,158,278 bp[2] End 122,175,273 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa right ventricle parotid gland Skeletal muscle tissue of biceps brachii secondary oocyte superficial temporal artery duodenum male germ cell skin of hip sperm Top expressed in neural layer of retina spermatocyte spermatid genital tubercle epiblast tail of embryo olfactory bulb ventricular zone ganglionic eminence thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity protein domain specific binding protein N-terminus binding phosphatase activity protein-containing complex binding protein serine/threonine phosphatase activity metal ion binding protein phosphatase 1 binding protein C-terminus binding protein binding protein phosphatase binding hydrolase activity protein kinase binding lamin binding RNA binding Cellular component cytoplasm cytosol nuclear speck focal adhesion dendritic spine chromosome nucleoplasm mitochondrial outer membrane midbody PTW/PP1 phosphatase complex nucleolus mitochondrion cleavage furrow chromosome, centromeric region nucleus kinetochore protein phosphatase type 1 complex protein-containing complex presynapse postsynapse glutamatergic synapse Biological process regulation of nucleocytoplasmic transport rhythmic process protein dephosphorylation circadian regulation of gene expression cell division regulation of circadian rhythm neuron differentiation glycogen metabolic process cell cycle entrainment of circadian clock by photoperiod sister chromatid cohesion carbohydrate metabolic process positive regulation of glial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5501 434233 Ensembl ENSG00000186298 ENSMUSG00000004455 UniProt P36873 P63087 RefSeq (mRNA) NM_001244974 NM_002710 XM_006508415 RefSeq (protein) NP_001231903 NP_002701 NP_038664 Location (UCSC) Chr 12: 110.72 – 110.74 Mb Chr 5: 122.16 – 122.18 Mb PubMed search [3] [4]
Wikidata
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Interactions

PPP1CC has been shown to interact with PPP1R15A,^[6][7] SMARCB1,^[6] TLX1^[8] and PPP1R9B.^[9][10]