TLX1

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.^{[5][6][7][8][9]}

TLX1
Identifiers
Aliases	TLX1, HOX11, TCL3, T-cell leukemia homeobox 1, T cell leukemia homeobox 1
External IDs	OMIM: 186770; MGI: 98769; HomoloGene: 4031; GeneCards: TLX1; OMA:TLX1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.31 Start 101,131,300 bp[1] End 101,137,789 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 38.45 cM Start 45,139,119 bp[2] End 45,145,382 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen testicle minor salivary glands gonad right lobe of liver mucosa of transverse colon duodenum tonsil ventricle of the heart left ventricle Top expressed in dorsal mesentery tongue middle ear submandibular gland outer ear auricle skin of external ear female urethra male urethra Eustachian tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3195 21908 Ensembl ENSG00000107807 ENSMUSG00000025215 UniProt P31314 P43345 RefSeq (mRNA) NM_001195517 NM_005521 NM_021901 RefSeq (protein) NP_001182446 NP_005512 n/a Location (UCSC) Chr 10: 101.13 – 101.14 Mb Chr 19: 45.14 – 45.15 Mb PubMed search [3] [4]
Wikidata
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Interactions

TLX1 has been shown to interact with PPP1CC,^[10] PPP2CB^[10] and PPP2CA.^[10]