PPP2CB

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.^[5]

PPP2CB
Identifiers
Aliases	PPP2CB, PP2Abeta, PP2CB, protein phosphatase 2 catalytic subunit beta
External IDs	OMIM: 176916; MGI: 1321161; HomoloGene: 37889; GeneCards: PPP2CB; OMA:PPP2CB - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 30,774,457 bp[1] End 30,814,314 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A4|8 20.63 cM Start 34,089,653 bp[2] End 34,109,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons superior vestibular nucleus subthalamic nucleus lateral nuclear group of thalamus optic nerve postcentral gyrus external globus pallidus bronchial epithelial cell jejunal mucosa pars reticulata Top expressed in spermatid molar granulocyte spermatocyte left colon seminiferous tubule ventricular zone medial ganglionic eminence parotid gland endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity metal ion binding protein binding hydrolase activity protein serine/threonine phosphatase activity protein C-terminus binding tau protein binding Cellular component cytoplasm cytosol spindle pole protein phosphatase type 2A complex chromosome chromosome, centromeric region extracellular exosome cytoskeleton nucleus Biological process response to antibiotic response to endoplasmic reticulum stress apoptotic mitochondrial changes regulation of gene expression response to hydrogen peroxide proteasome-mediated ubiquitin-dependent protein catabolic process protein dephosphorylation negative regulation of Ras protein signal transduction response to lead ion peptidyl-threonine dephosphorylation peptidyl-serine dephosphorylation positive regulation of microtubule binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5516 19053 Ensembl ENSG00000104695 ENSMUSG00000009630 UniProt P62714 P62715 RefSeq (mRNA) NM_004156 NM_001009552 NM_017374 RefSeq (protein) NP_001009552 NP_059070 Location (UCSC) Chr 8: 30.77 – 30.81 Mb Chr 8: 34.09 – 34.11 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.^[6]

Interactions

PPP2CB has been shown to interact with TLX1,^[7] PPP2R1B^[8] and PPP2R1A.^[8][9]

See also

• PPP2CA