PPP2R5A

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.^[5]

PPP2R5A
Identifiers
Aliases	PPP2R5A, B56A, PR61A, protein phosphatase 2 regulatory subunit B'alpha, B56alpha
External IDs	OMIM: 601643; MGI: 2388479; HomoloGene: 55961; GeneCards: PPP2R5A; OMA:PPP2R5A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 212,285,410 bp[1] End 212,361,853 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H6 Start 191,084,172 bp[2] End 191,135,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte rectum bone marrow subcutaneous adipose tissue Skeletal muscle tissue of rectus abdominis right lung blood right coronary artery Skeletal muscle tissue of biceps brachii cervix epithelium Top expressed in granulocyte ankle joint esophagus muscle of thigh genital tubercle lip right kidney tail of embryo neural layer of retina superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase binding protein binding protein phosphatase regulator activity phosphoprotein phosphatase activity protein phosphatase activator activity Cellular component cytoplasm M band protein phosphatase type 2A complex Z discdkac chromosome, centromeric region membrane nucleus chromosome cytosol centrosome Biological process negative regulation of lipid kinase activity positive regulation of protein dephosphorylation signal transduction negative regulation of protein localization to plasma membrane protein dephosphorylation regulation of phosphoprotein phosphatase activity regulation of protein autophosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5525 226849 Ensembl ENSG00000066027 ENSMUSG00000026626 UniProt Q15172 Q6PD03 RefSeq (mRNA) NM_006243 NM_001199756 NM_144880 RefSeq (protein) NP_001186685 NP_006234 NP_659129 Location (UCSC) Chr 1: 212.29 – 212.36 Mb Chr 1: 191.08 – 191.14 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.^[6]

Interactions

PPP2R5A has been shown to interact with:

• AXIN1,^[7]
• CTLA-4,^[8]
• PPP2CA,^[9][10]
• PPP2R1A,^[9][11]
• PPP2R1B,^{[9][11][10][12]} and
• PPP2R5C^[12]