PPP2R5C

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.^[5][6]

PPP2R5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IAE, 2JAK, 2NPP, 2NYL, 2NYM, 3FGA, 5JJA
Identifiers
Aliases	PPP2R5C, B56G, PR61G, protein phosphatase 2 regulatory subunit B'gamma, B56gamma
External IDs	OMIM: 601645; MGI: 1349475; HomoloGene: 135298; GeneCards: PPP2R5C; OMA:PPP2R5C - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.31 Start 101,761,798 bp[1] End 101,927,989 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 60.56 cM Start 110,413,554 bp[2] End 110,549,496 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell epithelium of colon granulocyte Achilles tendon Brodmann area 23 tonsil C1 segment rectum ventricular zone Top expressed in neural layer of retina atrioventricular valve primary visual cortex spermatid superior frontal gyrus primary motor cortex spermatocyte cingulate gyrus seminiferous tubule medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein phosphatase regulator activity protein phosphatase activator activity Cellular component protein phosphatase type 2A complex chromosome, centromeric region nucleus chromosome nucleoplasm Golgi apparatus cytosol Biological process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction negative regulation of cell population proliferation proteasome-mediated ubiquitin-dependent protein catabolic process regulation of phosphatidylinositol 3-kinase signaling regulation of phosphoprotein phosphatase activity regulation of protein autophosphorylation protein dephosphorylation negative regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5527 26931 Ensembl ENSG00000078304 ENSMUSG00000017843 UniProt Q13362 Q60996 RefSeq (mRNA) NM_001161725 NM_001161726 NM_002719 NM_178586 NM_178587 NM_178588 NM_001352912 NM_001352913 NM_001352914 NM_001352915 NM_001352916 NM_001037934 NM_001081457 NM_001081458 NM_001135001 NM_012023 NM_001364204 NM_001364205 NM_001364206 NM_001364207 NM_001364208 NM_001364209 NM_001364210 NM_001364211 NM_001364212 NM_001364213 NM_001364214 NM_001373949 NM_001373950 NM_001373951 NM_001373952 NM_001373953 NM_001373954 RefSeq (protein) NP_001155197 NP_001155198 NP_002710 NP_848701 NP_848702 NP_001339841 NP_001339842 NP_001339843 NP_001339844 NP_001339845 NP_001074926 NP_001074927 NP_001128473 NP_036153 NP_001351133 NP_001351134 NP_001351135 NP_001351136 NP_001351137 NP_001351138 NP_001351139 NP_001351140 NP_001351141 NP_001351142 NP_001351143 NP_001360878 NP_001360879 NP_001360880 NP_001360881 NP_001360882 NP_001360883 Location (UCSC) Chr 14: 101.76 – 101.93 Mb Chr 12: 110.41 – 110.55 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to the Protein phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

PPP2R5C has been shown to interact with PPP2R1B,^[7] PPP2CA^[7][8][9] and PPP2R5A.^[10]