PPP5C

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.^[5][6]

PPP5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A17, 1S95, 1WAO, 2BUG, 3H60, 3H61, 3H62, 3H63, 3H64, 3H66, 3H67, 3H68, 3H69, 4ZX2, 4ZVZ
Identifiers
Aliases	PPP5C, PP5, PPP5, PPT, protein phosphatase 5 catalytic subunit
External IDs	OMIM: 600658; MGI: 102666; HomoloGene: 4550; GeneCards: PPP5C; OMA:PPP5C - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 46,347,087 bp[1] End 46,392,981 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A2|7 9.15 cM Start 16,738,565 bp[2] End 16,761,849 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence anterior pituitary ventricular zone right hemisphere of cerebellum apex of heart stromal cell of endometrium right auricle of heart right frontal lobe right adrenal gland Top expressed in neural layer of retina yolk sac superior frontal gyrus tail of embryo dentate gyrus of hippocampal formation granule cell cerebellar cortex muscle of thigh gastrula epiblast ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity heat shock protein binding microtubule binding ADP binding protein serine/threonine phosphatase activity signal transducer activity metal ion binding protein binding RNA binding identical protein binding G-protein alpha-subunit binding hydrolase activity ATP binding lipid binding Hsp90 protein binding Cellular component perikaryon membrane intracellular membrane-bounded organelle plasma membrane soma proximal dendrite neuron projection nucleus cell periphery nucleoplasm cytoplasm cytosol Biological process negative regulation of protein phosphorylation positive regulation of glucocorticoid receptor signaling pathway protein heterooligomerization protein dephosphorylation negative regulation of cell death cellular response to cadmium ion transcription, DNA-templated MAPK cascade cellular response to DNA damage stimulus response to morphine response to lead ion protein complex oligomerization positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to hydrogen peroxide negative regulation of neuron death DNA repair mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5536 19060 Ensembl ENSG00000011485 ENSMUSG00000003099 UniProt P53041 Q60676 RefSeq (mRNA) NM_006247 NM_001204284 NM_011155 RefSeq (protein) NP_001191213 NP_006238 NP_035285 Location (UCSC) Chr 19: 46.35 – 46.39 Mb Chr 7: 16.74 – 16.76 Mb PubMed search [3] [4]
Wikidata
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Interactions

PPP5C has been shown to interact with ASK1,^[7] CRY2^[8] GNA12.^[9] and Rac1,^[10]