PPRC1

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.^[5][6][7]

PPRC1
Identifiers
Aliases	PPRC1, PRC, peroxisome proliferator-activated receptor gamma, coactivator-related 1, PPARG related coactivator 1
External IDs	OMIM: 617462; MGI: 2385096; HomoloGene: 9006; GeneCards: PPRC1; OMA:PPRC1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 102,132,994 bp[1] End 102,150,333 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 46,033,325 bp[2] End 46,061,354 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube oocyte skin of abdomen upper lobe of left lung left ovary right ovary anterior pituitary secondary oocyte skin of leg gonad Top expressed in otic placode epiblast otic vesicle tail of embryo saccule primitive streak Gonadal ridge human fetus morula morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclear receptor coactivator activity nucleic acid binding transcription coregulator activity RNA binding transcription factor binding Cellular component nucleus nucleoplasm Biological process positive regulation of DNA-binding transcription factor activity mitochondrion organization positive regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23082 226169 Ensembl ENSG00000148840 ENSMUSG00000055491 UniProt Q5VV67 Q6NZN1 RefSeq (mRNA) NM_001288727 NM_001288728 NM_015062 NM_001081214 NM_145504 NM_001346801 RefSeq (protein) NP_001275656 NP_001275657 NP_055877 NP_001074683 NP_001333730 Location (UCSC) Chr 10: 102.13 – 102.15 Mb Chr 19: 46.03 – 46.06 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.^[7]

Interactions

PPRC1 has been shown to interact with USF2.^[8]