USF2

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.^[5][6]

USF2
Identifiers
Aliases	USF2, FIP, bHLHb12, upstream transcription factor 2, c-fos interacting
External IDs	OMIM: 600390; MGI: 99961; HomoloGene: 2527; GeneCards: USF2; OMA:USF2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,268,962 bp[1] End 35,279,821 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 19.27 cM Start 30,644,673 bp[2] End 30,656,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum apex of heart right frontal lobe C1 segment ganglionic eminence left ovary anterior pituitary right ovary right lobe of thyroid gland ventricular zone Top expressed in neural layer of retina ventricular zone granulocyte superior frontal gyrus lip muscle of thigh dentate gyrus of hippocampal formation granule cell primary visual cortex yolk sac genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein dimerization activity protein homodimerization activity DNA-binding transcription factor activity bHLH transcription factor binding protein binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular membrane-bounded organelle nucleus nucleoplasm Biological process regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter by glucose regulation of transcription by RNA polymerase II late viral transcription transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter by glucose lipid homeostasis lactation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7392 22282 Ensembl ENSG00000105698 ENSMUSG00000058239 UniProt Q15853 Q64705 RefSeq (mRNA) NM_003367 NM_207291 NM_001321150 NM_011680 RefSeq (protein) NP_001308079 NP_003358 NP_997174 NP_035810 Location (UCSC) Chr 19: 35.27 – 35.28 Mb Chr 7: 30.64 – 30.66 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.^[6]

Interactions

USF2 has been shown to interact with USF1 (human gene),^[7][8] PPRC1^[9] and BRCA1.^[10]

Regulation

The USF2 gene is repressed by the microRNA miR-10a.^[11]