PRKAR1B

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.^[5][6][7]

PRKAR1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DIN, 4F9K
Identifiers
Aliases	PRKAR1B, PRKAR1, protein kinase cAMP-dependent type I regulatory subunit beta, MASNS
External IDs	OMIM: 176911; MGI: 97759; HomoloGene: 37665; GeneCards: PRKAR1B; OMA:PRKAR1B - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 549,197 bp[1] End 727,650 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 77.74 cM Start 139,003,061 bp[2] End 139,135,756 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 right frontal lobe cingulate gyrus anterior cingulate cortex frontal pole Brodmann area 9 amygdala nucleus accumbens right hemisphere of cerebellum hypothalamus Top expressed in substantia nigra motor neuron dorsal tegmental nucleus ventromedial nucleus dorsomedial hypothalamic nucleus prefrontal cortex subiculum pontine nuclei anterior amygdaloid area ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein kinase A catalytic subunit binding cAMP binding cAMP-dependent protein kinase regulator activity cAMP-dependent protein kinase inhibitor activity protein binding 3',5'-cyclic-GMP phosphodiesterase activity Cellular component cytosol membrane plasma membrane ciliary base cAMP-dependent protein kinase complex synapse Schaffer collateral - CA1 synapse hippocampal mossy fiber to CA3 synapse glutamatergic synapse Biological process regulation of protein phosphorylation activation of protein kinase A activity cellular response to glucagon stimulus blood coagulation negative regulation of cAMP-dependent protein kinase activity protein phosphorylation renal water homeostasis learning or memory modulation of chemical synaptic transmission regulation of synaptic vesicle cycle cGMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5575 19085 Ensembl ENSG00000188191 ENSMUSG00000025855 UniProt P31321 P12849 RefSeq (mRNA) NM_001164758 NM_001164759 NM_001164760 NM_001164761 NM_001164762 NM_002735 NM_001253890 NM_008923 NM_001359097 NM_001359098 NM_001359099 NM_001359100 NM_001359101 RefSeq (protein) NP_001158230 NP_001158231 NP_001158232 NP_001158233 NP_001158234 NP_002726 NP_001240819 NP_032949 NP_001346026 NP_001346027 NP_001346028 NP_001346029 NP_001346030 Location (UCSC) Chr 7: 0.55 – 0.73 Mb Chr 5: 139 – 139.14 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Mutations in PRKAR1B cause neurodegenerative disorder.^[8]

Interactions

PRKAR1B has been shown to interact with AKAP1^[9] and PRKAR1A.^[9][10]