AKAP1

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.^[5][6][7]

AKAP1
Identifiers
Aliases	AKAP1, AKAP, AKAP121, AKAP149, AKAP84, D-PPP1R43, PRKA1, SAKAP84, TDRD17, A-kinase anchoring protein 1
External IDs	OMIM: 602449; MGI: 104729; HomoloGene: 31165; GeneCards: AKAP1; OMA:AKAP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 57,085,092 bp[1] End 57,121,346 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 88,721,618 bp[2] End 88,755,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm body of tongue Skeletal muscle tissue of rectus abdominis left testis thoracic diaphragm right testis cardia saphenous vein vena cava Top expressed in seminiferous tubule spermatid neural layer of retina brown adipose tissue digastric muscle right ventricle soleus muscle extraocular muscle primary oocyte thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase A regulatory subunit binding nucleic acid binding RNA binding Cellular component integral component of membrane mitochondrion mitochondrial outer membrane membrane cytosol Biological process regulation of protein kinase A signaling blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8165 11640 Ensembl ENSG00000121057 ENSMUSG00000018428 UniProt Q92667 O08715 RefSeq (mRNA) NM_001242902 NM_001242903 NM_003488 NM_139275 NM_001370423 NM_001370424 NM_001370425 NM_001370426 NM_001370427 NM_001042541 NM_009648 RefSeq (protein) NP_001229831 NP_001229832 NP_003479 NP_001357352 NP_001357353 NP_001357354 NP_001357355 NP_001357356 NP_001036006 NP_033778 Location (UCSC) Chr 17: 57.09 – 57.12 Mb Chr 11: 88.72 – 88.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.^[7]

Interactions

AKAP1 has been shown to interact with:

• C3orf15,^[8]
• MYCBP,^[8][9]
• PRKAR1A,^[10][11]
• PRKAR1B,^[10] and
• PRKAR2A.^[11][12]