PSKH2

Protein Serine/threonine-protein kinase H2 is a Ser/Thr protein pseudokinase that is encoded by the PSKH2 gene, and forms part of the CAMK subfamily of protein kinases. Homologues of PSKH2 are absent in rodents, but a PSKH2-like sequence is present in most vertebrate genomes.^[3] PSKH2 does not bind to ATP, nor does it phosphorylate any known substrate in cells, simplistically because it lacks the catalytic Asp residue in the HRD motif. The PSKH2 protein interactome is complex, and involves a number of membrane-associated proteins alongside the HSP90 Cdc37 molecular chaperone complex.^[4] PSKH2 exhibits significant sequence homology to the catalytically active Ser/Thr kinase PSKH1.^[5]

PSKH2
Identifiers
Aliases	PSKH2, protein serine kinase H2
External IDs	HomoloGene: 57203; GeneCards: PSKH2; OMA:PSKH2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 86,047,109 bp[1] End 86,088,621 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle human kidney renal cortex placenta thigh muscle of thigh prefrontal cortex substantia nigra n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity ATP binding kinase activity protein serine/threonine kinase activity Cellular component intracellular anatomical structure Biological process protein phosphorylation phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85481 n/a Ensembl ENSG00000147613 n/a UniProt Q96QS6 n/a RefSeq (mRNA) NM_033126 n/a RefSeq (protein) NP_149117 n/a Location (UCSC) Chr 8: 86.05 – 86.09 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human