PTPN7

Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.^[5][6]

PTPN7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZC0, 2A3K, 2GP0, 2GPH, 2HVL, 2QDC, 2QDM, 2QDP, 3D42, 3D44, 3O4S, 3O4T, 3O4U
Identifiers
Aliases	PTPN7, BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI, protein tyrosine phosphatase, non-receptor type 7, protein tyrosine phosphatase non-receptor type 7
External IDs	OMIM: 176889; MGI: 2156893; HomoloGene: 15411; GeneCards: PTPN7; OMA:PTPN7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,147,013 bp[1] End 202,161,588 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 135,060,438 bp[2] End 135,073,055 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node bone marrow cells appendix thymus blood spleen right testis left testis putamen Top expressed in thymus granulocyte bone marrow spleen striatum of neuraxis embryo pharynx neck yolk sac jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity Cellular component cytoplasmic side of plasma membrane cytoskeleton cytoplasm cytosol nucleoplasm Biological process dephosphorylation peptidyl-tyrosine dephosphorylation protein dephosphorylation cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5778 320139 Ensembl ENSG00000143851 ENSMUSG00000031506 UniProt P35236 Q8BUM3 RefSeq (mRNA) NM_001199797 NM_002832 NM_080588 NM_080589 NM_001364877 NM_001364878 NM_177081 NM_001356382 RefSeq (protein) NP_001186726 NP_002823 NP_542155 NP_001351806 NP_001351807 NP_796055 NP_001343311 Location (UCSC) Chr 1: 202.15 – 202.16 Mb Chr 1: 135.06 – 135.07 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

PTPN7 has been shown to interact with MAPK3^[7][8][9] and MAPK1.^[7][9]