PTRF

For the mathematics journal, see Probability Theory and Related Fields.

Polymerase I and transcript release factor, also known as Cavin1, Cavin-1 or PTRF, is a protein which in humans is encoded by the PTRF gene.^[5][6]

CAVIN1
Identifiers
Aliases	CAVIN1, CAVIN, CGL4, cavin-1, FKSG13, PTRF, polymerase I and transcript release factor, caveolae associated protein 1
External IDs	OMIM: 603198; MGI: 1277968; HomoloGene: 7499; GeneCards: CAVIN1; OMA:CAVIN1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,402,449 bp[1] End 42,423,256 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.95 cM Start 100,847,559 bp[2] End 100,861,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery tendon of biceps brachii popliteal artery tibial arteries Descending thoracic aorta saphenous vein ascending aorta left coronary artery body of uterus gastric mucosa Top expressed in lactiferous gland ascending aorta aortic valve umbilical cord white adipose tissue ankle joint gastrula subcutaneous adipose tissue plantaris muscle tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding rRNA primary transcript binding protein binding RNA binding identical protein binding Cellular component cytoplasm cytosol membrane nucleoplasm endoplasmic reticulum mitochondrion caveola membrane raft nucleus plasma membrane intracellular membrane-bounded organelle protein-containing complex Biological process termination of RNA polymerase I transcription regulation of transcription, DNA-templated transcription initiation from RNA polymerase I promoter DNA-templated transcription, termination transcription, DNA-templated rRNA transcription positive regulation of cell motility protein secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284119 19285 Ensembl ENSG00000177469 ENSMUSG00000004044 UniProt Q6NZI2 O54724 RefSeq (mRNA) NM_012232 NM_008986 NM_001359105 NM_027160 RefSeq (protein) NP_036364 NP_033012 NP_001346034 Location (UCSC) Chr 17: 42.4 – 42.42 Mb Chr 11: 100.85 – 100.86 Mb PubMed search [3] [4]
Wikidata
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Function

PTRF (Cavin1) has been shown to be crucial for caveola formation and function.^[7] Deformation caveolae promotes the translocation of cavin-1 from caveolae to the nucleus^[8]

Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.^[9][10]

PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.^[11]

Interactions

PTRF (Cavin1) forms trimers with Cavin2 and Cavin3 in caveola formation and has been shown to interact with other membrane associating proteins such as EHD2 and caveolins.^[12]

PTRF has been shown to interact with ZNF148.^[13]