Parathyroid hormone 2 receptor

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.^[5]

PTH2R
Identifiers
Aliases	PTH2R, PTHR2, parathyroid hormone 2 receptor
External IDs	OMIM: 601469; MGI: 2180917; HomoloGene: 3701; GeneCards: PTH2R; OMA:PTH2R - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 208,359,714 bp[1] End 208,854,503 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 33.05 cM Start 65,321,215 bp[2] End 65,428,403 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell testicle human kidney secondary oocyte islet of Langerhans Brodmann area 9 prefrontal cortex right frontal lobe Brodmann area 23 middle temporal gyrus Top expressed in medial geniculate nucleus spermatid embryo embryo lumbar spinal ganglion blastocyst medial dorsal nucleus medial ganglionic eminence neural tube lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding G protein-coupled receptor activity parathyroid hormone receptor activity transmembrane signaling receptor activity signal transducer activity G protein-coupled peptide receptor activity peptide hormone binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5746 213527 Ensembl ENSG00000144407 ENSMUSG00000025946 UniProt P49190 Q91V95 RefSeq (mRNA) NM_001309516 NM_005048 NM_139270 RefSeq (protein) NP_001296445 NP_005039 NP_001358834 NP_001358835 NP_001358836 NP_644676 Location (UCSC) Chr 2: 208.36 – 208.85 Mb Chr 1: 65.32 – 65.43 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.^[5]

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.^[6]

Mechanism

It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by G_s protein, which activates adenylyl cyclase.^[7]

See also

• Parathyroid hormone receptor