Prolactin-releasing peptide

Prolactin-releasing peptide (PrRP) is a peptide hormone that in humans is encoded by the PRLH gene.^[5] PrRP stimulates prolactin (PRL) release and regulates the expression of prolactin through binding to the prolactin-releasing peptide receptor (GPR10).^[6]

PRLH
Identifiers
Aliases	PRLH, PRH, PRRP, prolactin releasing hormone
External IDs	OMIM: 602663; MGI: 3644668; HomoloGene: 9291; GeneCards: PRLH; OMA:PRLH - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 237,566,574 bp[1] End 237,567,175 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 90,880,830 bp[2] End 90,881,749 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tendon of biceps brachii right auricle of heart skin of thigh right uterine tube optic nerve face sensory organ lower respiratory tract mucosa of nose Top expressed in blastocyst granulocyte bone marrow cerebellar cortex colon hypothalamus duodenum human kidney proximal tubule yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide hormone activity prolactin-releasing peptide receptor binding hormone activity Cellular component cytoplasm extracellular region Biological process tissue homeostasis reduction of food intake in response to dietary excess energy reserve metabolic process lipid metabolism G protein-coupled receptor signaling pathway response to glucose response to insulin regulation of multicellular organism growth fat cell differentiation autonomic nervous system development response to dietary excess response to peptide hormone eating behavior feeding behavior regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51052 623503 Ensembl ENSG00000071677 ENSMUSG00000090550 UniProt P81277 G3UWC3 RefSeq (mRNA) NM_015893 NM_001101647 RefSeq (protein) NP_056977 NP_001095117 Location (UCSC) Chr 2: 237.57 – 237.57 Mb Chr 1: 90.88 – 90.88 Mb PubMed search [3] [4]
Wikidata
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Description

PrRP has 20 amino acids, and is a member of the RFamide peptide family.

During the discovery process, PrRP was found to be a ligand for an orphan G-protein coupled receptor (GPR 10). Preliminary in vitro studies showed it to stimulate the secretion of prolactin from lactotropic cells, hence its name. Now, however, the function of PrRP in the brain is understood in terms of negative regulation of appetite.^[7]

PrRP is produced by noradrenergic neurons A1 and A2 in the solitary nucleus, and also by neurons in the hypothalamus.^[7]