RAB11A

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.^[5][6]

RAB11A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OIV, 1OIW, 1OIX, 1YZK, 2D7C, 2GZD, 2GZH, 2HV8, 4C4P, 4D0L, 4D0M, 4LWZ, 4LX0, 4UJ3, 4UJ4, 4UJ5, 5C4G, 5C46, 5EUQ
Identifiers
Aliases	RAB11A, YL8, member RAS oncogene family
External IDs	OMIM: 605570; MGI: 1858202; HomoloGene: 37903; GeneCards: RAB11A; OMA:RAB11A - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,726,054 bp[1] End 65,891,989 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 64,622,581 bp[2] End 64,645,040 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium oral cavity mucosa of pharynx vulva amniotic fluid skin of thigh right adrenal gland right adrenal cortex rectum gallbladder Top expressed in lip granulocyte superior surface of tongue esophagus right kidney corneal stroma embryo superior frontal gyrus atrioventricular valve ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding myosin V binding GTPase activity microtubule binding syntaxin binding protein binding Cellular component extracellular exosome transport vesicle cytoplasm mitochondrion multivesicular body trans-Golgi network Golgi apparatus cytosol kinetochore microtubule axon spindle pole membrane centrosome perinuclear region of cytoplasm plasma membrane cleavage furrow cytoplasmic vesicle membrane cytoplasmic vesicle vesicle endosome phagocytic vesicle recycling endosome recycling endosome membrane postsynaptic recycling endosome microtubule organizing center protein-containing complex intracellular membrane-bounded organelle Schaffer collateral - CA1 synapse glutamatergic synapse intracellular anatomical structure Biological process regulation of vesicle-mediated transport positive regulation of G2/M transition of mitotic cell cycle multivesicular body assembly cell cycle astral microtubule organization regulation of long-term neuronal synaptic plasticity establishment of protein localization to membrane cytokinesis positive regulation of axon extension establishment of vesicle localization renal water homeostasis regulation of multivesicular body size establishment of protein localization to organelle neuron projection development protein localization to plasma membrane plasma membrane to endosome transport mitotic spindle assembly regulation of protein transport protein transport mitotic metaphase plate congression exosomal secretion vesicle-mediated transport positive regulation of epithelial cell migration melanosome transport ciliary basal body-plasma membrane docking positive regulation of protein localization to plasma membrane neurotransmitter receptor transport, endosome to postsynaptic membrane post-translational protein modification transport intracellular protein transport exocytosis regulation of cytokinesis Rab protein signal transduction vesicle-mediated transport in synapse amyloid-beta clearance by transcytosis small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8766 53869 Ensembl ENSG00000103769 ENSMUSG00000004771 UniProt P62491 P62492 RefSeq (mRNA) NM_004663 NM_001206836 NM_017382 RefSeq (protein) NP_001193765 NP_004654 NP_059078 Location (UCSC) Chr 15: 65.73 – 65.89 Mb Chr 9: 64.62 – 64.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport.^[7]

Rab-11a controls intracellular trafficking of the innate immune receptor TLR4, and thereby also receptor signaling^[8]

Interactions

RAB11A has been shown to interact with:

• RAB11FIP1,^[9][10][11]
• RAB11FIP2,^[12][9][13]
• RAB11FIP3,^[9]
• RAB11FIP4,^[14] and
• RAB11FIP5^[9][13][15]
• Moesin^[16]