RAB4A

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.^[5]

RAB4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YU9, 1Z0K, 2BMD, 2BME
Identifiers
Aliases	RAB4A, HRES-1, HRES-1/RAB4, HRES1, RAB4, member RAS oncogene family
External IDs	OMIM: 179511; MGI: 105069; HomoloGene: 101538; GeneCards: RAB4A; OMA:RAB4A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 229,271,062 bp[1] End 229,305,894 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E2|8 72.19 cM Start 124,532,724 bp[2] End 124,562,026 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus parotid gland pars compacta olfactory zone of nasal mucosa palpebral conjunctiva human penis right ventricle pars reticulata endothelial cell Achilles tendon Top expressed in parotid gland seminal vesicula lacrimal gland yolk sac submandibular gland right kidney ascending aorta cerebellar cortex left lobe of liver duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GDP binding ATPase binding GTP binding protein binding GTPase activity ATPase activator activity syntaxin binding ionotropic glutamate receptor binding Cellular component cytoplasm recycling endosome vesicle cytosol endosome membrane intracellular membrane-bounded organelle insulin-responsive compartment plasma membrane perinuclear region of cytoplasm extracellular exosome cytoplasmic vesicle membrane postsynaptic recycling endosome early endosome membrane recycling endosome membrane anchored component of synaptic vesicle membrane Biological process regulation of endocytosis antigen processing and presentation positive regulation of ATP-dependent activity Rab protein signal transduction protein transport phosphatidylinositol biosynthetic process intracellular protein transport small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5867 19341 Ensembl ENSG00000168118 ENSMUSG00000019478 UniProt P20338 P56371 RefSeq (mRNA) NM_001271998 NM_004578 NM_009003 RefSeq (protein) NP_001258927 NP_004569 NP_004569.2 NP_033029 Location (UCSC) Chr 1: 229.27 – 229.31 Mb Chr 8: 124.53 – 124.56 Mb PubMed search [3] [4]
Wikidata
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Interactions

RAB4A has been shown to interact with:

• CD2AP,^[6]
• KIF3B,^[7]
• RAB11FIP1,^[8]
• RABEP1,^[9] and
• STX4.^[10]