STX4

Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.^[5][6][7]

STX4
Identifiers
Aliases	STX4, STX4A, p35-2, syntaxin 4
External IDs	OMIM: 186591; MGI: 893577; HomoloGene: 105435; GeneCards: STX4; OMA:STX4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 31,032,889 bp[1] End 31,042,975 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,423,466 bp[2] End 127,448,191 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment granulocyte skin of leg skin of abdomen upper lobe of left lung canal of the cervix right lung left uterine tube sural nerve left adrenal cortex Top expressed in Ileal epithelium motor neuron lip yolk sac muscle of thigh granulocyte fossa superior frontal gyrus neural layer of retina condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding sphingomyelin phosphodiesterase activator activity SNARE binding Cellular component cytoplasm integral component of membrane cytosol endosome membrane synaptic vesicle plasma membrane myelin sheath adaxonal region dendritic spine synapse intracellular anatomical structure cell surface vacuole trans-Golgi network basolateral plasma membrane somatodendritic compartment specific granule lateral loop perinuclear region of cytoplasm storage vacuole extracellular exosome lamellipodium SNARE complex extracellular space phagocytic vesicle membrane endomembrane system presynaptic membrane phagocytic vesicle presynaptic active zone membrane postsynapse glutamatergic synapse Biological process positive regulation of eosinophil degranulation positive regulation of cell migration organelle fusion synaptic vesicle fusion to presynaptic active zone membrane response to hydroperoxide positive regulation of catalytic activity post-Golgi vesicle-mediated transport regulation of exocytosis vesicle docking positive regulation of protein localization to plasma membrane positive regulation of chemotaxis positive regulation of cell population proliferation positive regulation of protein localization to cell surface regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of insulin secretion involved in cellular response to glucose stimulus intracellular protein transport neurotransmitter transport vesicle-mediated transport SNARE complex assembly positive regulation of cell adhesion long-term potentiation vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane transport exocytosis vesicle fusion cytokine-mediated signaling pathway cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6810 20909 Ensembl ENSG00000103496 ENSMUSG00000030805 UniProt Q12846 P70452 RefSeq (mRNA) NM_001272095 NM_001272096 NM_004604 NM_009294 RefSeq (protein) NP_001259024 NP_001259025 NP_004595 NP_033320 Location (UCSC) Chr 16: 31.03 – 31.04 Mb Chr 7: 127.42 – 127.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STX4 has been shown to interact with:

• Gelsolin,^[8]
• NAPA,^[9]
• RAB4A,^[10]
• SNAP-25,^{[11][12][13][14]}
• SNAP23,^{[12][14][15][16][17][18][19][20]}
• STXBP1,^[11][21]
• STXBP5,^[22]
• Syntaxin binding protein 3,^[21][22]
• TXLNB,^[23]
• VAMP2,^{[13][18][24][25]}
• VAMP3,^{[9][15][18][26]} and
• Vesicle-associated membrane protein 8.^[18][26]