RAC2

"Rac2" redirects here. For the second game in the Ratchet & Clank series, see Ratchet & Clank: Going Commando.

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.^[5] It is encoded by the gene RAC2.^[6]

RAC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DS6, 2W2T, 2W2V, 2W2X
Identifiers
Aliases	RAC2, EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2, IMD73B, IMD73C, IMD73A
External IDs	OMIM: 602049; MGI: 97846; HomoloGene: 55699; GeneCards: RAC2; OMA:RAC2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,225,270 bp[1] End 37,244,448 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,443,367 bp[2] End 78,456,983 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen bone marrow bone marrow cells appendix monocyte trabecular bone thymus lymph node Top expressed in granulocyte tibiofemoral joint thymus spleen mesenteric lymph nodes blood ankle joint fetal liver hematopoietic progenitor cell bone marrow stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein kinase regulator activity GTPase activity protein binding Cellular component cytoplasm cytosol phagocytic vesicle membrane nuclear envelope membrane focal adhesion plasma membrane actin filament extracellular exosome lamellipodium intracellular anatomical structure Biological process regulation of respiratory burst lymphocyte aggregation regulation of T cell proliferation positive regulation of protein targeting to mitochondrion regulation of hydrogen peroxide metabolic process actin filament organization regulation of cell-substrate adhesion regulation of neutrophil migration bone resorption platelet activation chemotaxis cell projection assembly positive regulation of cell population proliferation regulation of mast cell chemotaxis positive regulation of neutrophil chemotaxis regulation of mast cell degranulation regulation of protein kinase activity positive regulation of lamellipodium assembly regulation of small GTPase mediated signal transduction actin cytoskeleton organization signal transduction small GTPase mediated signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5880 19354 Ensembl ENSG00000128340 ENSMUSG00000033220 UniProt P15153 Q05144 RefSeq (mRNA) NM_002872 NM_009008 RefSeq (protein) NP_002863 NP_033034 Location (UCSC) Chr 22: 37.23 – 37.24 Mb Chr 15: 78.44 – 78.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.^[6]

Interactions

Rac2 has been shown to interact with ARHGDIA^[7][8] and Nitric oxide synthase 2A.^[9]

See also

• NADPH oxidase