RANBP3

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.^[5][6]

RANBP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRF, 2Y8F, 2Y8G
Identifiers
Aliases	RANBP3, RAN binding protein 3
External IDs	OMIM: 603327; MGI: 1919060; HomoloGene: 136516; GeneCards: RANBP3; OMA:RANBP3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 5,916,139 bp[1] End 5,978,142 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 56,980,294 bp[2] End 57,018,764 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone ganglionic eminence stromal cell of endometrium gallbladder left testis muscle layer of sigmoid colon gastric mucosa popliteal artery tibial arteries Top expressed in spermatocyte ventricular zone epiblast Ileal epithelium yolk sac neural layer of retina primitive streak spermatid secondary oocyte dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function R-SMAD binding protein binding GTPase activator activity Cellular component nucleoplasm nucleus cytoplasm centrosome nuclear pore Biological process protein transport intracellular transport RNA export from nucleus ubiquitin-dependent protein catabolic process protein import into nucleus spindle organization positive regulation of GTPase activity positive regulation of mitotic centrosome separation G1/S transition of mitotic cell cycle protein export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8498 71810 Ensembl ENSG00000031823 ENSMUSG00000002372 UniProt Q9H6Z4 Q9CT10 RefSeq (mRNA) NM_001300865 NM_003624 NM_007320 NM_007321 NM_007322 NM_001252466 NM_001252467 NM_027933 RefSeq (protein) NP_001287794 NP_003615 NP_015559 NP_015561 NP_001239395 NP_001239396 NP_082209 Location (UCSC) Chr 19: 5.92 – 5.98 Mb Chr 17: 56.98 – 57.02 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

RANBP3 has been shown to interact with RCC1^[5][7] and XPO1.^[8][9]