RANBP9

Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene.^[5][6]

RANBP9
Identifiers
Aliases	RANBP9, Ranbp9, IBAP-1, Ibap1, RanBPM, BPM-L, BPM90, RanBP7, RAN binding protein 9
External IDs	OMIM: 603854; MGI: 1928741; HomoloGene: 38057; GeneCards: RANBP9; OMA:RANBP9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p23 Start 13,621,498 bp[1] End 13,711,835 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A4 Start 43,556,151 bp[2] End 43,634,758 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte Brodmann area 23 endothelial cell amniotic fluid oral cavity mucosa of pharynx skin of thigh human penis gingival epithelium Top expressed in zygote secondary oocyte spermatid spermatocyte ascending aorta seminiferous tubule aortic valve granulocyte tail of embryo genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding protein binding Cellular component cytoplasm cytosol plasma membrane membrane nucleus microtubule associated complex ubiquitin ligase complex Biological process negative regulation of ERK1 and ERK2 cascade microtubule nucleation axon guidance MAPK cascade protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10048 56705 Ensembl ENSG00000010017 ENSMUSG00000038546 UniProt Q96S59 P69566 RefSeq (mRNA) NM_005493 NM_019930 RefSeq (protein) NP_005484 NP_064314 NP_001391577 Location (UCSC) Chr 6: 13.62 – 13.71 Mb Chr 13: 43.56 – 43.63 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11.^[6]

Interactions

RANBP9 has been shown to interact with:

• Androgen receptor,^[7]
• C-Met,^[8]
• DISC1,^[9]
• DYRK1B,^[10]
• Glucocorticoid receptor,^[7]
• HIPK2^[11]
• MKLN1,^[12]
• S100A7,^[13] and
• USP11.^[14]