RANGAP1

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.^[5][6]

RANGAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z5S, 2GRN, 2GRO, 2GRP, 2GRQ, 2GRR, 2IY0, 3UIN, 3UIO, 3UIP, 5D2M, 2IO2, 2IO3
Identifiers
Aliases	RANGAP1, Fug1, RANGAP, SD, Ran GTPase activating protein 1
External IDs	OMIM: 602362; MGI: 103071; HomoloGene: 55700; GeneCards: RANGAP1; OMA:RANGAP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,244,779 bp[1] End 41,286,187 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 38.21 cM Start 81,588,449 bp[2] End 81,629,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis Brodmann area 10 right frontal lobe cingulate gyrus anterior cingulate cortex skin of abdomen Brodmann area 9 skin of leg middle frontal gyrus Top expressed in dentate gyrus of hippocampal formation granule cell superior surface of tongue spermatid yolk sac visual cortex superior frontal gyrus seminiferous tubule gallbladder primary visual cortex epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cadherin binding RNA binding GTPase activator activity ubiquitin protein ligase binding Cellular component intracellular membrane-bounded organelle cytoplasmic periphery of the nuclear pore complex nuclear pore chromosome dendrite nuclear pore cytoplasmic filaments mitotic spindle chromosome, centromeric region cytoskeleton nucleus kinetochore axon cytoplasm cytoplasm cytosol aggresome perinuclear region of cytoplasm nuclear envelope nucleoplasm spindle nuclear membrane Biological process cellular response to vasopressin protein sumoylation cellular response to peptide hormone stimulus negative regulation of protein export from nucleus response to axon injury signal transduction sister chromatid cohesion activation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5905 19387 Ensembl ENSG00000100401 ENSMUSG00000022391 UniProt P46060 P46061 RefSeq (mRNA) NM_001278651 NM_002883 NM_001317930 NM_001146174 NM_011241 NM_001358622 RefSeq (protein) NP_001265580 NP_001304859 NP_002874 NP_001139646 NP_035371 NP_001345551 Location (UCSC) Chr 22: 41.24 – 41.29 Mb Chr 15: 81.59 – 81.63 Mb PubMed search [3] [4]
Wikidata
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Further information on RanGAP proteins in non-human species: RanGAP

Function

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Rangap1 (Fug1), the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.^[6]

Interactions

RanGAP1 is a trafficking protein which helps transport other proteins from the cytoplasm to the nucleus. Small ubiquitin-related modifier needs to be associated with it before it can be localized at the nuclear pore.^[7]

RANGAP1 has been shown to interact with:

• Ran,^[8][9][10] and
• UBE2I.^[11][12][13]