RBBP5

Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene.^[5][6]

RBBP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P4F, 4X8N, 4X8P, 5F6K, 5F6L
Identifiers
Aliases	RBBP5, RBQ3, SWD1, retinoblastoma binding protein 5, RB binding protein 5, histone lysine methyltransferase complex subunit
External IDs	OMIM: 600697; MGI: 1918367; HomoloGene: 3709; GeneCards: RBBP5; OMA:RBBP5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,086,142 bp[1] End 205,122,015 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 132,405,103 bp[2] End 132,433,397 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell secondary oocyte testicle gonad Achilles tendon islet of Langerhans ganglionic eminence ventricular zone stromal cell of endometrium monocyte Top expressed in hand condyle fossa zygote trigeminal ganglion otolith organ tail of embryo utricle neural layer of retina genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylated histone binding protein binding histone methyltransferase activity (H3-K4 specific) histone-lysine N-methyltransferase activity Cellular component MLL1 complex nucleolus MLL3/4 complex nucleus nucleoplasm histone methyltransferase complex Set1C/COMPASS complex Biological process response to estrogen histone H3-K4 methylation regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus beta-catenin-TCF complex assembly post-translational protein modification regulation of megakaryocyte differentiation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5929 213464 Ensembl ENSG00000117222 ENSMUSG00000026439 UniProt Q15291 Q8BX09 RefSeq (mRNA) NM_001193272 NM_001193273 NM_005057 NM_172517 NM_001357486 NM_001357487 RefSeq (protein) NP_001180201 NP_001180202 NP_005048 NP_766105 NP_001344415 NP_001344416 Location (UCSC) Chr 1: 205.09 – 205.12 Mb Chr 1: 132.41 – 132.43 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.^[6]

Interactions

RBBP5 has been shown to interact with:

• ASCL2,^[7]
• MLL,^[8]
• MLL3,^[7] and
• NCOA6.^[7]