NCOA6

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.^[5][6][7]

NCOA6
Identifiers
Aliases	NCOA6, AIB3, ASC2, NRC, PRIP, RAP250, TRBP, nuclear receptor coactivator 6
External IDs	OMIM: 605299; MGI: 1929915; HomoloGene: 40920; GeneCards: NCOA6; OMA:NCOA6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 34,689,097 bp[1] End 34,825,651 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,232,576 bp[2] End 155,315,814 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence tibia epithelium of nasopharynx gingival epithelium parietal pleura pancreatic ductal cell visceral pleura ventricular zone urethra Top expressed in zygote secondary oocyte genital tubercle tail of embryo spermatocyte retinal pigment epithelium vestibular sensory epithelium primary oocyte stroma of bone marrow ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding protein binding enzyme binding estrogen receptor binding retinoid X receptor binding nuclear receptor coactivator activity thyroid hormone receptor binding transcription coactivator activity Cellular component intracellular membrane-bounded organelle transcription regulator complex nucleoplasm nucleus histone methyltransferase complex cytosol Biological process myeloid cell differentiation DNA recombination regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated DNA replication heart development brain development DNA-templated transcription, initiation response to hormone DNA repair intracellular estrogen receptor signaling pathway glucocorticoid receptor signaling pathway positive regulation of transcription by RNA polymerase II regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23054 56406 Ensembl ENSG00000198646 ENSMUSG00000038369 UniProt Q14686 Q9JL19 RefSeq (mRNA) NM_001242539 NM_014071 NM_001318240 NM_001242558 NM_019825 RefSeq (protein) NP_001229468 NP_001305169 NP_054790 n/a Location (UCSC) Chr 20: 34.69 – 34.83 Mb Chr 2: 155.23 – 155.32 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D₃, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.^[7]

Interactions

NCOA6 has been shown to interact with:

• ASCL2^[8] and
• Activating transcription factor 2,^[9]
• Androgen receptor,^[10]
• CREB-binding protein,^[11][12]
• DNA-PKcs,^[13]
• E2F1,^[14]
• EP300,^[13]
• Estrogen receptor alpha,^[11][15]
• Estrogen receptor beta,^[12][15]
• HBXIP,^[16]
• HIST2H3C,^[8]
• HSF1,^[17]
• Ku70,^[13][18]
• Ku80,^[13][18]
• Liver X receptor beta,^[12]
• MLL3,^[8]
• RBBP5,^[8]
• Retinoblastoma protein,^[10]
• Retinoic acid receptor alpha,^[11][12][13]
• Retinoid X receptor alpha,^{[11][12][15][16]}
• Src,^{[8][11][12][19]}
• TGS1,^[20][21]
• TUBA4A,^[8]
• TUBB,^[8]
• Thyroid hormone receptor alpha,^[11][19] and
• Thyroid hormone receptor beta.^{[11][12][13][15]}

See also

• Transcription coregulator