RBBP6

Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene.^[5][6][7]

RBBP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C7H, 2YSA, 2YUR, 3ZTG
Identifiers
Aliases	RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA, retinoblastoma binding protein 6, RB binding protein 6, ubiquitin ligase
External IDs	OMIM: 600938; MGI: 894835; HomoloGene: 136812; GeneCards: RBBP6; OMA:RBBP6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 24,537,693 bp[1] End 24,572,863 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 122,564,909 bp[2] End 122,601,780 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell sperm gastric mucosa left ovary mucosa of paranasal sinus right ovary right uterine tube left testis right testis skin of abdomen Top expressed in tail of embryo genital tubercle medullary collecting duct neural layer of retina ventricular zone Ileal epithelium thymus spermatid plantaris muscle renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding zinc ion binding nucleic acid binding metal ion binding ubiquitin-protein transferase activity ubiquitin protein ligase activity transferase activity RNA binding protein kinase binding Cellular component nucleolus microtubule organizing center nucleus chromosome cytoplasm cytoskeleton cytosol centrosome nuclear speck protein-containing complex Biological process in utero embryonic development embryonic organ development regulation of DNA replication DNA replication cellular response to DNA damage stimulus protein ubiquitination multicellular organism growth somite development mRNA processing protein polyubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5930 19647 Ensembl ENSG00000122257 ENSMUSG00000030779 UniProt Q7Z6E9 P97868 RefSeq (mRNA) NM_006910 NM_018703 NM_032626 NM_011247 NM_175023 RefSeq (protein) NP_008841 NP_061173 NP_116015 NP_035377 NP_778188 NP_001390011 NP_001390012 Location (UCSC) Chr 16: 24.54 – 24.57 Mb Chr 7: 122.56 – 122.6 Mb PubMed search [3] [4]
Wikidata
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Function

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.^[7]

Interactions

RBBP6 has been shown to interact with Y box binding protein 1.^[8]