Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.^[5] YBX1 is an RNA binding protein^[6] that stabilises messenger RNAs modified with N6-methyladenosine.^[7]

YBX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H95
Identifiers
Aliases	YBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDs	OMIM: 154030; MGI: 99146; HomoloGene: 88707; GeneCards: YBX1; OMA:YBX1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 42,682,418 bp[1] End 42,703,805 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 119,135,178 bp[2] End 119,151,801 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis ganglionic eminence ventricular zone Achilles tendon gastrocnemius muscle muscle of thigh skeletal muscle tissue left ventricle stromal cell of endometrium Top expressed in Ileal epithelium primitive streak tail of embryo abdominal wall medial ganglionic eminence endothelial cell of lymphatic vessel seminiferous tubule choroid plexus of fourth ventricle migratory enteric neural crest cell maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding RNA binding nucleic acid binding GTPase binding double-stranded DNA binding single-stranded DNA binding chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm CRD-mediated mRNA stability complex nuclear membrane intracellular membrane-bounded organelle U12-type spliceosomal complex nucleoplasm extracellular region cytoplasmic stress granule extracellular exosome nucleus histone pre-mRNA 3'end processing complex cytosol ribonucleoprotein complex Biological process CRD-mediated mRNA stabilization mRNA splicing, via spliceosome regulation of transcription, DNA-templated mRNA processing transcription by RNA polymerase II protein localization to cytoplasmic stress granule transcription, DNA-templated positive regulation of cell division positive regulation of transcription by RNA polymerase II in utero embryonic development RNA splicing negative regulation of striated muscle cell differentiation negative regulation of transcription by RNA polymerase II Notch signaling pathway cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4904 22608 Ensembl ENSG00000065978 ENSMUSG00000028639 UniProt P67809 P62960 RefSeq (mRNA) NM_004559 NM_011732 RefSeq (protein) NP_004550 NP_035862 Location (UCSC) Chr 1: 42.68 – 42.7 Mb Chr 4: 119.14 – 119.15 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

YBX1 is a potential drug target in cancer therapy.^[8] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.^[8] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

DNA repair

The mitochondria of human cells possess a repair pathway for DNA base pair mismatches that is distinct from the DNA mismatch repair pathway of the nucleus.^[9] This mitochondrial pathway includes participation of Y box binding protein 1 (designated YB-1 or YBX1), that likely acts in the mismatch binding and recognition steps of mismatch repair.^[9]

Interactions

Y box binding protein 1 has been shown to interact with:

• ANKRD2,^[10]
• CTCF,^[11]
• P53,^[10][12]
• PCNA,^[13]
• RBBP6,^[14] and
• SFRS9.^[15]