RCOR1

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.^[5][6]

RCOR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IW5, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1, 4BAY, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN, 5L3D, 5L3B, 5L3C, 4XBF
Identifiers
Aliases	RCOR1, COREST, RCOR, REST corepressor 1
External IDs	OMIM: 607675; MGI: 106340; HomoloGene: 32246; GeneCards: RCOR1; OMA:RCOR1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.31-q32.32 Start 102,592,649 bp[1] End 102,730,561 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 60.93 cM Start 111,005,785 bp[2] End 111,082,335 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gums gingival epithelium bone marrow mucosa of pharynx palpebral conjunctiva bone marrow cells jejunal mucosa skin of thigh human penis Top expressed in hair follicle Gonadal ridge epithelium of stomach human fetus left lung lobe left colon atrium crypt of lieberkuhn of small intestine Paneth cell saccule More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding transcription factor binding histone deacetylase activity transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component DNA repair complex transcription repressor complex nucleus transcription regulator complex nucleoplasm Biological process histone H4 deacetylation viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated blood coagulation transcription, DNA-templated negative regulation of transcription by RNA polymerase II chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23186 217864 Ensembl ENSG00000089902 ENSMUSG00000037896 UniProt Q9UKL0 Q8CFE3 RefSeq (mRNA) NM_015156 NM_198023 RefSeq (protein) NP_055971 NP_932140 Location (UCSC) Chr 14: 102.59 – 102.73 Mb Chr 12: 111.01 – 111.08 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).^[6]

Interactions

RCOR1 has been shown to interact with

• HDAC1,^[7][8]
• HDAC2,^[7][8]
• HMG20B,^[7]
• REST^[5] and
• PHF21A.^[7][9]