REFPROP

REFPROP is a software program for the prediction of thermophysical properties of fluids, developed by the National Institute of Standards and Technology (NIST).^[1][2][3]

REFPROP
Developer	National Institute of Standards and Technology (NIST)
Initial release	1989; 36 years ago (1989)
Stable release	10.0 / 2018
Written in	Fortran
Platform	x86-64
Available in	English
Type	Thermophysical property software
License	Proprietary
Website	www.nist.gov/srd/refprop

The primary component of REFPROP is an equation of state for each implemented fluid. For most pure fluids, the equation of state is obtained by fitting an expression for the Helmholtz free energy to experimental data. This formulation allows the computation of all equilibrium properties of the fluid, such as density, temperature, pressure, sound speed, heat capacity, second virial coefficients, vapor pressures, saturated liquid and vapor densities, enthalpy of vaporization, entropy, and the Joule-Thomson coefficient.^[1]

REFPROP also predicts surface tension, viscosity, and thermal conductivity for many fluids, either using extended corresponding states formulations or fluid-specific equations fit directly to experimental data.

Various methods are used to compute the analogous properties of fluid mixtures.

The full list of fluids properties implemented in REFPROP v10.0 can be found in Table 2 of Huber, et al. (2022).^[1]

List of implemented fluids

REFPROP v10.0 implements equation of state models for 147 pure fluids, listed in Table 1.^[1] Except for F₃N, R-13, R-123, and R-152a, all of these are Helmholtz free energy formulations.

REFPROP v10.0 also predicts surface tension, viscosity, and thermal conductivity for most of the listed fluids.

Table 1: List of pure fluids implemented in REFPROP v10.0

Short name	Full name	Short formula	CAS number
1,3-Butadiene	Buta-1,3-diene	C4H6	106-99-0
1-Butyne	But-1-yne	C4H6	107-00-6
1-Pentene	Pent-1-ene	C5H10	109-67-1
2,2-Dimethylbutane	2,2-Dimethylbutane	C6H14	75-83-2
2,3-Dimethylbutane	2,3-Dimethylbutane	C6H14	79-29-8
3-Methylpentane	3-Methylpentane	C6H14	96-14-0
Acetone	Propanone	C3H6O	67-64-1
Acetylene	Ethyne	C2H2	74-86-2
Ammonia	Ammonia	NH3	7664-41-7
Argon	Argon	Ar	7440-37-1
Benzene	Benzene	C6H6	71-43-2
Butane	n-Butane	C4H10	106-97-8
Butene	1-Butene	C4H8	106-98-9
Carbon dioxide	Carbon dioxide	CO2	124-38-9
Carbon monoxide	Carbon monoxide	CO	630-08-0
Carbonyl sulfide	Carbon oxide sulfide	COS	463-58-1
Chlorine	Chlorine	Cl2	7782-50-5
Chlorobenzene	Chlorobenzene	C6H5Cl	108-90-7
cis-Butene	cis-2-Butene	C4H8	590-18-1
Cyclobutene	1-Cyclobutene	C4H6	822-35-5
Cyclohexane	Cyclohexane	C6H12	110-82-7
Cyclopentane	Cyclopentane	C5H10	287-92-3
Cyclopropane	Cyclopropane	C3H6	75-19-4
D4	Octamethylcyclotetrasiloxane	C8H24O4Si4	556-67-2
D5	Decamethylcyclopentasiloxane	C10H30O5Si5	541-02-6
D6	Dodecamethylcyclohexasiloxane	C12H36O6Si6	540-97-6
DEA	2,2'-Iminodiethanol	C4H11NO2	111-42-2
Decane	Decane	C10H22	124-18-5
Deuterium	Deuterium	D2	7782-39-0
Dichloroethane	1,2-Dichloroethane	C2H4Cl2	107-06-2
Diethyl ether	Diethyl ether	C4H10O	60-29-7
Dimethyl carbonate	Dimethyl ester carbonic acid	C3H6O3	616-38-6
Dimethylether	Methoxymethane	C2H6O	115-10-6
Docosane	Docosane	C22H46	629-97-0
Dodecane	Dodecane	C12H26	112-40-3
Ethane	Ethane	C2H6	74-84-0
Ethanol	Ethyl alcohol	C2H6O	64-17-5
Ethylene glycol	1,2-Ethandiol	C2H6O2	107-21-1
Ethyl benzene	Phenylethane	C8H10	100-41-4
Ethylene	Ethene	C2H4	74-85-1
Ethylene oxide	Ethylene oxide	C2H4O	75-21-8
Fluorine	Fluorine	F2	7782-41-4
Heavy water	Deuterium oxide	D2O	7789-20-0
Helium	Helium-4	He	7440-59-7
Heptane	Heptane	C7H16	142-82-5
Hexadecane	Hexadecane	C16H34	544-76-3
Hexane	Hexane	C6H14	110-54-3
Hydrogen	Hydrogen	H2	1333-74-0
Hydrogen chloride	Hydrogen chloride	HCl	7647-01-0
Hydrogen sulfide	Hydrogen sulfide	H2S	7783-06-4
Isobutane	2-Methylpropane	C4H10	75-28-5
Isobutene	2-Methyl-1-propene	C4H8	115-11-7
Isohexane	2-Methylpentane	C6H14	107-83-5
Isooctane	2,2,4-Trimethylpentane	C8H18	540-84-1
Isopentane	2-Methylbutane	C5H12	78-78-4
Krypton	Krypton	Kr	7439-90-9
MD2M	Decamethyltetrasiloxane	C10H30O3Si4	141-62-8
MD3M	Dodecamethylpentasiloxane	C12H36O4Si5	141-63-9
MD4M	Tetradecamethylhexasiloxane	C14H42O5Si6	107-52-8
MDM	Octamethyltrisiloxane	C8H24O2Si3	107-51-7
MEA	Ethanolamine	C2H7NO	141-43-5
Methane	Methane	CH4	74-82-8
Methanol	Methanol	CH4O	67-56-1
Methyl linoleate	Methyl(Z,Z)-9,12-octadecadienate	C19H34O2	112-63-0
Methyl linolenate	Methyl(Z,Z,Z)-9,12,15-octadecatrienoate	C19H32O2	301-00-8
Methyl oleate	Methylcis-9-octadecenoate	C19H36O2	112-62-9
Methyl palmitate	Methyl hexadecanoate	C17H34O2	112-39-0
Methyl stearate	Methyl octadecanoate	C19H38O2	112-61-8
Methyl cyclohexane	Methylcyclohexane	C7H14	108-87-2
MM	Hexamethyldisiloxane	C6H18OSi2	107-46-0
m-Xylene	1,3-Dimethylbenzene	C8H10	108-38-3
Neon	Neon	Ne	7440-01-9
Neopentane	2,2-Dimethylpropane	C5H12	463-82-1
Nitrogen	Nitrogen	N2	7727-37-9
Nitrogen trifluoride	Nitrogen trifluoride	F3N	7783-54-2
Nitrous oxide	Dinitrogen monoxide	N2O	10024-97-2
Nonane	Nonane	C9H20	111-84-2
Novec649,1230	1,1,1,2,2,4,5,5,5-Nonafluoro-4-(trifluoromethyl)-3-pentanone	C6F12O	756-13-8
Octane	Octane	C8H18	111-65-9
Orthohydrogen	Orthohydrogen	H2	-
Oxygen	Oxygen	O2	7782-44-7
o-Xylene	1,2-Dimethylbenzene	C8H10	95-47-6
Parahydrogen	Parahydrogen	H2	-
Pentane	Pentane	C5H12	109-66-0
Perfluorobutane	Decafluorobutane	C4F10	355-25-9
Perfluorohexane	Tetradecafluorohexane	C6F14	355-42-0
Perfluoropentane	Dodecafluoropentane	C5F12	678-26-2
Propadiene	1,2-Propadiene	C3H4	463-49-0
Propane	Propane	C3H8	74-98-6
Propyl cyclohexane	n-Propyl cyclohexane	C9H18	1678-92-8
Propylene	Propene	C3H6	115-07-1
Propylene oxide	1,2-Epoxy propane	C3H6O	75-56-9
Propyne	Propyne	C3H4	74-99-7
p-Xylene	1,4-Dimethylbenzene	C8H10	106-42-3
R11	Trichlorofluoromethane	CCl3F	75-69-4
R1123	Trifluoroethylene	C2HF3	359-11-5
R113	1,1,2-Trichloro-1,2,2-trifluoroethane	C2Cl3F3	76-13-1
R114	1,2-Dichlorotetrafluoroethane	C2Cl2F4	76-14-2
R115	Chloropentafluoroethane	C2ClF5	76-15-3
R116	Hexafluoroethane	C2F6	76-16-4
R12	Dichlorodifluoromethane	CCl2F2	75-71-8
R1216	Hexafluoropropene	C3F6	116-15-4
R1224yd(Z)	(Z)-1-Chloro-2,3,3,3-tetrafluoropropene	C3HClF4	111512-60-8
R123	2,2-Dichloro-1,1,1-trifluoroethane	C2HCl2F3	306-83-2
R1233zd(E)	trans-1-Chloro-3,3,3-trifluoro-1-propene	C3H2ClF3	102687-65-0
R1234yf	2,3,3,3-Tetrafluoroprop-1-ene	C3F4H2	754-12-1
R1234ze(E)	trans-1,3,3,3-Tetrafluoropropene	C3F4H2	29118-24-9
R1234ze(Z)	cis-1,3,3,3-Tetrafluoropropene	C3F4H2	29118-25-0
R124	1-Chloro-1,2,2,2-tetrafluoroethane	C2HClF4	2837-89-0
R1243zf	3,3,3-Trifluoropropene	C3H3F3	677-21-4
R125	Pentafluoroethane	C2HF5	354-33-6
R13	Chlorotrifluoromethane	CClF3	75-72-9
R1336mzz(Z)	(Z)-1,1,1,4,4,4-Hexafluoro-2-butene	C4H2F6	692-49-9
R134a	1,1,1,2-Tetrafluoroethane	C2H2F4	811-97-2
R13I1	Trifluoroiodomethane	CF3I	2314-97-8
R14	Tetrafluoromethane	CF4	75-73-0
R141b	1,1-Dichloro-1-fluoroethane	C2H3Cl2F	1717-00-6
R142b	1-Chloro-1,1-difluoroethane	C2H3ClF2	75-68-3
R143a	1,1,1-Trifluoroethane	C2H3F3	420-46-2
R152a	1,1-Difluoroethane	C2H4F2	75-37-6
R161	Fluoroethane	C2H5F	353-36-6
R21	Dichlorofluoromethane	CHClF	75-43-4
R218	Octafluoropropane	C3F8	76-19-7
R22	Chlorodifluoromethane	CHClF2	75-45-6
R227ea	1,1,1,2,3,3,3-Heptafluoropropane	C3HF7	431-89-0
R23	Trifluoromethane	CHF3	75-46-7
R236ea	1,1,1,2,3,3-Hexafluoropropane	C3H2F6	431-63-0
R236fa	1,1,1,3,3,3-Hexafluoropropane	C3H2F6	690-39-1
R245ca	1,1,2,2,3-Pentafluoropropane	C3H3F5	679-86-7
R245fa	1,1,1,3,3-Pentafluoropropane	C3H3F5	460-73-1
R32	Difluoromethane	CH2F2	75-10-5
R365mfc	1,1,1,3,3-Pentafluorobutane	C4H5F5	406-58-6
R40	Methyl chloride	CH3Cl	74-87-3
R41	Fluoromethane	CH3F	593-53-3
RC318	Octafluorocyclobutane	C4F8	115-25-3
RE143a	Methyl trifluoromethyl ether	C2H3F3O	421-14-7
RE245cb2	Methyl pentafluoroethyl ether	C3H3F5O	22410-44-2
RE245fa2	2,2,2-Trifluoroethyl-difluoromethyl-ether	C3H3F5O	1885-48-9
RE347mcc(HFE7000)	1,1,1,2,2,3,3-Heptafluoro-3methoxypropane	C4H3F7O	375-03-1
Sulfur dioxide	Sulfur dioxide	O2S	7446-09-5
Sulfur hexafluoride	Sulfur hexafluoride	SF6	2551-62-4
Toluene	Methylbenzene	C7H8	108-88-3
trans-Butene	trans-2-Butene	C4H8	624-64-6
Undecane	Undecane	C11H24	1120-21-4
Vinyl chloride	Chloroethylene	C2H3Cl	75-01-4
Water	Water	H2O	7732-18-5
Xenon	Xenon	Xe	7440-63-3

See also

• Process engineering
• Prediction of viscosity
• Prediction of thermal conductivity
• Viscosity models for mixtures
• Theorem of corresponding states
• Departure function
• The International Association for the Properties of Water and Steam