REG1B

Lithostathine-1-beta is a protein that in humans is encoded by the REG1B gene.^[5][6]

REG1B
Identifiers
Aliases	REG1B, PSPS2, REGH, REGI-BETA, REGL, regenerating family member 1 beta
External IDs	OMIM: 167771; MGI: 97896; HomoloGene: 68517; GeneCards: REG1B; OMA:REG1B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 79,085,023 bp[1] End 79,088,019 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 78,372,606 bp[2] End 78,385,089 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans beta cell mucosa of ileum appendix duodenum apex of heart right coronary artery right uterine tube ectocervix Top expressed in pyloric antrum islet of Langerhans duodenum embryo morula blastocyst upper arm tibiofemoral joint triceps brachii muscle lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding transmembrane signaling receptor activity peptidoglycan binding oligosaccharide binding Cellular component extracellular region extracellular exosome extracellular space Biological process cell population proliferation positive regulation of cell population proliferation response to peptide hormone cell wall disruption in other organism antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5968 19693 Ensembl ENSG00000172023 ENSMUSG00000023140 UniProt P48304 Q08731 RefSeq (mRNA) NM_006507 NM_009043 RefSeq (protein) NP_006498 NP_033069 Location (UCSC) Chr 2: 79.09 – 79.09 Mb Chr 6: 78.37 – 78.39 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.^[6]