RGS10

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.^[5][6]

RGS10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DLR, 2I59, 2IHB
Identifiers
Aliases	RGS10, regulator of G protein signaling 10
External IDs	OMIM: 602856; MGI: 1915115; HomoloGene: 37710; GeneCards: RGS10; OMA:RGS10 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.11 Start 119,499,817 bp[1] End 119,542,719 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,975,345 bp[2] End 128,020,482 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte thymus granulocyte muscle layer of sigmoid colon trabecular bone periodontal fiber blood lymph node appendix rectum Top expressed in blood thymus mesenteric lymph nodes spermatid spermatocyte spinal ganglia tibiofemoral joint spleen nucleus accumbens lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity G-protein alpha-subunit binding protein binding GTPase activity Cellular component cytosol plasma membrane nucleus cytoplasm axon terminus soma dendritic spine Biological process G protein-coupled acetylcholine receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway response to amphetamine G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6001 67865 Ensembl ENSG00000148908 ENSMUSG00000030844 UniProt O43665 Q9CQE5 RefSeq (mRNA) NM_002925 NM_001005339 NM_026418 RefSeq (protein) NP_001005339 NP_002916 NP_080694 Location (UCSC) Chr 10: 119.5 – 119.54 Mb Chr 7: 127.98 – 128.02 Mb PubMed search [3] [4]
Wikidata
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Function

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

RGS10 has been shown to interact with SAP18^[7] and GNAI3.^[5]