SAP18

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.^[5][6]

SAP18
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2HDE
Identifiers
Aliases	SAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18
External IDs	OMIM: 602949; MGI: 3704317; HomoloGene: 4289; GeneCards: SAP18; OMA:SAP18 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.11 Start 21,140,514 bp[1] End 21,149,084 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D1 Start 96,551,974 bp[2] End 96,552,762 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus right ventricle tendon tendon of biceps brachii corpus epididymis Achilles tendon caput epididymis bronchial epithelial cell biceps brachii Skeletal muscle tissue of biceps brachii Top expressed in primary oocyte yolk sac embryo embryo neural tube stomach lens zygote epiblast proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein binding histone deacetylase activity RNA binding Cellular component histone deacetylase complex nuclear speck exon-exon junction complex nucleoplasm ASAP complex nucleus cytoplasm cytosol nuclear body Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II mRNA processing regulation of alternative mRNA splicing, via spliceosome transcription, DNA-templated negative regulation of mRNA splicing, via spliceosome RNA splicing positive regulation of apoptotic process negative regulation of nucleic acid-templated transcription histone deacetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10284 100041953 Ensembl ENSG00000150459 ENSMUSG00000061104 UniProt O00422 n/a RefSeq (mRNA) NM_005870 NM_001366643 NM_001142441 RefSeq (protein) NP_005861 NP_001353572 n/a Location (UCSC) Chr 13: 21.14 – 21.15 Mb Chr 8: 96.55 – 96.55 Mb PubMed search [3] [4]
Wikidata
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Function

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.^[6] Additionally, SAP18s splice variants are implicated in apoptotic cycles.^[7]

Interactions

SAP18 has been shown to interact with

• POLE2,^[8][9] and
• RGS10.^[10]