RGS12

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[5][6]

RGS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBZ, 2KV8
Identifiers
Aliases	RGS12, regulator of G protein signaling 12
External IDs	OMIM: 602512; MGI: 1918979; HomoloGene: 2195; GeneCards: RGS12; OMA:RGS12 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 3,293,021 bp[1] End 3,439,913 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B2|5 17.96 cM Start 35,106,789 bp[2] End 35,196,988 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone mucosa of esophagus skin of leg right uterine tube skin of abdomen right frontal lobe right hemisphere of cerebellum prefrontal cortex ectocervix Top expressed in spermatocyte lip hand ventricular zone genital tubercle Rostral migratory stream spermatid ganglionic eminence dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase regulator activity GTPase activator activity GTPase activity Cellular component cytoplasm cell projection nuclear matrix synapse condensed nuclear chromosome cell junction dendrite plasma membrane nucleus nucleolus cytosol Biological process regulation of G protein-coupled receptor signaling pathway transcription, DNA-templated positive regulation of GTPase activity negative regulation of signal transduction signal transduction regulation of catalytic activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6002 71729 Ensembl ENSG00000159788 ENSMUSG00000029101 UniProt O14924 Q8CGE9 RefSeq (mRNA) NM_002926 NM_198227 NM_198229 NM_198230 NM_198430 NM_198432 NM_198587 NM_001394154 NM_001394155 NM_001394156 NM_001394157 NM_001394158 NM_001394159 NM_001394161 NM_001394162 NM_001394163 NM_001163512 NM_173402 RefSeq (protein) NP_002917 NP_937870 NP_937872 NP_001156984 NP_775578 NP_001390400 NP_001390401 NP_001390402 NP_001390403 NP_001390404 NP_001390405 NP_001390406 NP_001390407 Location (UCSC) Chr 4: 3.29 – 3.44 Mb Chr 5: 35.11 – 35.2 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.^[6]

Interactions

RGS12 has been shown to interact with GNAI1,^[7] GNAI3,^[7] and the kappa opioid receptor.^[8]