RGS17

Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene.^[5][6]

RGS17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZV4
Identifiers
Aliases	RGS17, RGS-17, RGSZ2, hregulator of G-protein signaling 17, regulator of G protein signaling 17
External IDs	OMIM: 607191; MGI: 1927469; HomoloGene: 8242; GeneCards: RGS17; OMA:RGS17 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.2 Start 153,004,459 bp[1] End 153,131,282 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 5,775,663 bp[2] End 5,872,400 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell tendon of biceps brachii cartilage tissue middle temporal gyrus islet of Langerhans ganglionic eminence Brodmann area 23 mucosa of paranasal sinus pancreatic ductal cell testicle Top expressed in superior colliculus dorsomedial hypothalamic nucleus zygote central gray substance of midbrain secondary oocyte ventral tegmental area inferior colliculi paraventricular nucleus of hypothalamus nucleus of stria terminalis pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component cytoplasm neuron projection cell junction synapse membrane nucleus plasma membrane cytoplasmic vesicle Biological process positive regulation of GTPase activity negative regulation of signal transduction response to amphetamine G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26575 56533 Ensembl ENSG00000091844 ENSMUSG00000019775 UniProt Q9UGC6 Q9QZB0 RefSeq (mRNA) NM_012419 NM_001161822 NM_019958 RefSeq (protein) NP_036551 NP_001155294 NP_064342 Location (UCSC) Chr 6: 153 – 153.13 Mb Chr 10: 5.78 – 5.87 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.^[6] Along with RGS4, RGS9 and RGS14,^[7][8] RGS17 plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs.^[9][10]

Clinical significance

RGS17 is a putative lung cancer susceptibility gene in the lung cancer associated locus on chromosome 6q in humans.^[11] RGS17 is overexpressed in lung and prostate cancers, induces cAMP production, CREB phosphorylation and CREB responsive gene expression[2]. Expression of RGS17 is required for maintenance of proliferation in lung tumor cell lines.^[12]