RIC8A

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.^[5][6][7]

RIC8A
Identifiers
Aliases	RIC8A, RIC8, RIC8 guanine nucleotide exchange factor A
External IDs	OMIM: 609146; MGI: 2141866; HomoloGene: 23331; GeneCards: RIC8A; OMA:RIC8A - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 207,708 bp[1] End 215,113 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 140,436,870 bp[2] End 140,444,285 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ventricular zone granulocyte ganglionic eminence smooth muscle tissue gallbladder anterior pituitary prefrontal cortex right coronary artery decidua Top expressed in Paneth cell Rostral migratory stream aortic valve supraoptic nucleus external carotid artery fossa ascending aorta internal carotid artery condyle conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity guanyl-nucleotide exchange factor activity G-protein alpha-subunit binding Cellular component cytoplasm plasma membrane membrane Biological process visual learning G protein-coupled receptor signaling pathway positive regulation of GTPase activity cell migration involved in gastrulation cell-cell adhesion involved in gastrulation vasculature development in utero embryonic development adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway gastrulation response to light stimulus basement membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60626 101489 Ensembl ENSG00000177963 ENSMUSG00000025485 UniProt Q9NPQ8 Q3TIR3 RefSeq (mRNA) NM_001286134 NM_021932 NM_001386941 NM_001386942 NM_053194 RefSeq (protein) NP_001273063 NP_068751 NP_444424 Location (UCSC) Chr 11: 0.21 – 0.22 Mb Chr 7: 140.44 – 140.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RIC8A has been shown to interact with GNAO1,^[8] GNA13,^[9][8] GNAQ,^[8][10] GNAS complex locus,^[10] GNAI2,^[8] GNAI1^[8] and GNAI3.^[8]