RING1

E3 ubiquitin-protein ligase RING1 is an enzyme that in humans is encoded by the RING1 gene.^[5][6]

RING1
Identifiers
Aliases	RING1, RING1A, RNF1, ring finger protein 1
External IDs	OMIM: 602045; MGI: 1101770; HomoloGene: 68283; GeneCards: RING1; OMA:RING1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 33,208,500 bp[1] End 33,212,722 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 34,239,766 bp[2] End 34,243,654 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary right lobe of thyroid gland left lobe of thyroid gland right hemisphere of cerebellum right uterine tube canal of the cervix left ovary body of uterus right ovary Top expressed in neural layer of retina ascending aorta muscle of thigh aortic valve yolk sac female urethra granulocyte lip parotid gland ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding metal ion binding protein binding ubiquitin-protein transferase activator activity transferase activity Cellular component nuclear speck nuclear body sex chromatin ubiquitin ligase complex nucleoplasm PcG protein complex nucleus cytosol PRC1 complex Biological process regulation of transcription, DNA-templated histone H2A monoubiquitination transcription, DNA-templated protein ubiquitination regulation of catalytic activity negative regulation of transcription, DNA-templated histone ubiquitination camera-type eye morphogenesis anterior/posterior pattern specification negative regulation of G0 to G1 transition chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6015 19763 Ensembl ENSG00000204227 ENSMUSG00000024325 UniProt Q06587 O35730 RefSeq (mRNA) NM_002931 NM_009066 RefSeq (protein) NP_002922 NP_033092 Location (UCSC) Chr 6: 33.21 – 33.21 Mb Chr 17: 34.24 – 34.24 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.^[6]

Interactions

RING1 has been shown to interact with CBX8,^[7] BMI1^[8][9] and RYBP.^[10][11]